Publication:
HIV and aging: Insights from the Asia Pacific HIV Observational Database (APHOD)

Issued Date

2015-03-01

Resource Type

Article

ISSN

14681293
14642662

DOI

10.1111/hiv.12188

Other identifier(s)

2-s2.0-84922700435

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

HIV Medicine. Vol.16, No.3 (2015), 152-160

Suggested Citation

N. Han, S. T. Wright, C. C. O'Connor, J. Hoy, S. Ponnampalavanar, M. Grotowski, H. X. Zhao, A. Kamarulzaman, D. Ellis, M. Bloch, T. Franic, S. Agrawal, L. McCann, N. Cunningham, T. Vincent, D. Allen, J. L. Little, D. Smith, C. Gray, D. Baker, R. Vale, D. J. Templeton, C. Dijanosic, E. Jackson, K. McCallum, S. Taylor, D. Cooper, A. Carr, F. Lee, K. Hesse, K. Sinn, R. Norris, R. Finlayson, I. Prone, J. Shakeshaft, K. Brown, C. McGrath, V. McGrath, S. Halligan, L. Wray, P. Read, H. Lu, D. Couldwell, V. Furner, J. Watson, C. Lawrence, B. Mulhall, Matthew Law, K. Petoumenos, H. McManus, C. Bendall, M. Boyd, A. Kulatunga, P. Knibbs, J. Chuah, M. Ngieng, B. Dickson, D. Russell, S. Downing, D. Sowden, J. Broom, K. Taing, C. Johnston, K. McGill, D. Orth, D. Youds, M. Kelly, A. Gibson, H. Magon, W. Donohue, R. Moore, S. Edwards, R. Liddle, P. Locke, N. J. Roth, J. Nicolson, H. Lau, T. Read, J. Silvers, W. Zeng, K. Watson, M. Bryant, S. Price, I. Woolley, M. Giles, T. Korman, J. Williams, D. Nolan, J. Skett, J. Robinson, C. V. Mean, V. Saphonn, K. Vohith, F. J. Zhang HIV and aging: Insights from the Asia Pacific HIV Observational Database (APHOD). HIV Medicine. Vol.16, No.3 (2015), 152-160. doi:10.1111/hiv.12188 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36505

Research Projects

Organizational Units

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Journal Issue

Thesis

Title

HIV and aging: Insights from the Asia Pacific HIV Observational Database (APHOD)

Author(s)

N. Han
 S. T. Wright
 C. C. O'Connor
 J. Hoy
 S. Ponnampalavanar
 M. Grotowski
 H. X. Zhao
 A. Kamarulzaman
 D. Ellis
 M. Bloch
 T. Franic
 S. Agrawal
 L. McCann
 N. Cunningham
 T. Vincent
 D. Allen
 J. L. Little
 D. Smith
 C. Gray
 D. Baker
 R. Vale
 D. J. Templeton
 C. Dijanosic
 E. Jackson
 K. McCallum
 S. Taylor
 D. Cooper
 A. Carr
 F. Lee
 K. Hesse
 K. Sinn
 R. Norris
 R. Finlayson
 I. Prone
 J. Shakeshaft
 K. Brown
 C. McGrath
 V. McGrath
 S. Halligan
 L. Wray
 P. Read
 H. Lu
 D. Couldwell
 V. Furner
 J. Watson
 C. Lawrence
 B. Mulhall
 Matthew Law
 K. Petoumenos
 H. McManus
 C. Bendall
 M. Boyd
 A. Kulatunga
 P. Knibbs
 J. Chuah
 M. Ngieng
 B. Dickson
 D. Russell
 S. Downing
 D. Sowden
 J. Broom
 K. Taing
 C. Johnston
 K. McGill
 D. Orth
 D. Youds
 M. Kelly
 A. Gibson
 H. Magon
 W. Donohue
 R. Moore
 S. Edwards
 R. Liddle
 P. Locke
 N. J. Roth
 J. Nicolson
 H. Lau
 T. Read
 J. Silvers
 W. Zeng
 K. Watson
 M. Bryant
 S. Price
 I. Woolley
 M. Giles
 T. Korman
 J. Williams
 D. Nolan
 J. Skett
 J. Robinson
 C. V. Mean
 V. Saphonn
 K. Vohith
 F. J. Zhang

Other Contributor(s)

Beijing Ditan Hospital
 University of New South Wales (UNSW) Australia
 RPA Sexual Health
 The University of Sydney
 Monash University
 University of Malaya Medical Centre
 Hunter New England Area Health Service - Clinic 468
 General Medical Practice
 Holdsworth House General Practice
 Holden Street Clinic
 Lismore Sexual Health Services
 East Sydney Doctors
 Blue Mountains Sexual Health and HIV Clinic
 Tamworth Sexual Health Service
 St. Vincent's Hospital Sydney
 Nepean Sexual Health and HIV Clinic
 Illawarra Sexual Health
 Sydney Sexual Health Centre
 Parramatta Sexual Health Clinic , Sexually Transmitted Infections Research Centre
 Dubbo Sexual Health Centre
 National Association of People Living with HIV/AIDS
 National Aboriginal Community Controlled Health Organisation
 Royal Darwin Hospital
 Gold Coast Health Service District
 Cairns Sexual Health Service
 Sunshine Coast-Wide Bay Health Service District
 Brisbane Sexual Health and HIV Service
 Northside Clinic
 Prahran Market Clinic
 Melbourne Sexual Health Centre
 Alfred Hospital
 Monash Medical Centre
 Royal Perth Hospital
 National Center for HIV/AIDS
 Queen Elizabeth Hospital Hong Kong
 YR Gaitonde Centre for AIDS Research and Education
 Institute of Infectious Diseases

Abstract

© 2014 British HIV Association. Objectives: The proportion of people living with HIV/AIDS in the ageing population (>50 years old) is increasing. We aimed to explore the relationship between older age and treatment outcomes in HIV-positive persons from the Asia Pacific region. Methods: Patients from the Australian HIV Observational Database (AHOD) and the TREAT Asia HIV Observational Database (TAHOD) were included in the analysis. We used survival methods to assess the association between older age and all-cause mortality, as well as time to treatment modification. We used regression analyses to evaluate changes in CD4 counts after combination antiretroviral therapy (cART) initiation and determined the odds of detectable viral load, up to 24 months of treatment. Results: A total of 7142 patients were included in these analyses (60% in TAHOD and 40% in AHOD), of whom 25% were >50 years old. In multivariable analyses, those aged >50 years were at least twice as likely to die as those aged 30-39 years [hazard ratio (HR) for 50-59 years: 2.27; 95% confidence interval (CI) 1.34-3.83; HR for >60 years: 4.28; 95% CI 2.42-7.55]. The effect of older age on CD4 count changes was insignificant (p-trend=0.06). The odds of detectable viral load after cART initiation decreased with age (p-trend=<0.0001). The effect of older age on time to first treatment modification was insignificant (p-trend=0.21). We found no statistically significant differences in outcomes between AHOD and TAHOD participants for all endpoints examined. Conclusions: The associations between older age and typical patient outcomes in HIV-positive patients from the Asia Pacific region are similar in AHOD and TAHOD. Our data indicate that 'age effects' traverse the resource-rich and resource-limited divide and that future ageing-related findings might be applicable to each setting.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/36505

Collections

Scopus 2011-2015