Publication: Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial
Issued Date
2015-01-01
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ISSN
14470756
13418076
13418076
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2-s2.0-84924762599
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Obstetrics and Gynaecology Research. Vol.41, No.3 (2015), 402-410
Suggested Citation
Supatra Leelaphiwat, Theerayut Jongwutiwes, Srithean Lertvikool, Chotika Tabcharoen, Matchuporn Sukprasert, Sasivimol Rattanasiri, Sawaek Weerakiet Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial. Journal of Obstetrics and Gynaecology Research. Vol.41, No.3 (2015), 402-410. doi:10.1111/jog.12543 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/36676
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Title
Comparison of desogestrel/ethinyl estradiol plus spironolactone versus cyproterone acetate/ethinyl estradiol in the treatment of polycystic ovary syndrome: A randomized controlled trial
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Abstract
© 2014 The Authors. Abstract Aim To compare the effects of ethinyl estradiol (EE) 30 mcg/desogestrel 150 mcg plus spironolactone 25 mg/day (group A) versus EE 35 mcg/cyproterone acetate 2 mg (group B) on hyperandrogenism and metabolism in PCOS. Methods This was a randomized clinical study. Eighteen women in groups A and B received medications for three cycles. Acne score, androgens and metabolic parameters were assessed before and after treatment. Results One and two women in groups A and B, respectively, were excluded from the study. Both groups had significantly decreased acne score and free androgen index, and increased sex hormone-binding globulin levels. Cholesterol and high-density lipoprotein were significantly increased in group B, and androstenedione was significantly decreased in group A. The regular withdrawal bleeding was obtained in both groups. Conclusion Both regimens had quite similar efficacy on hyperandrogenism after three cycles of therapy and without any changes in metabolic parameters.