Publication: A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh
Issued Date
2016-10-13
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14712334
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2-s2.0-84992058852
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Mahidol University
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SCOPUS
Bibliographic Citation
BMC Infectious Diseases. Vol.16, No.1 (2016)
Suggested Citation
Rapeephan R. Maude, Aniruddha Ghose, Rasheda Samad, Hanna K. de Jong, Masako Fukushima, Lalith Wijedoru, Mahtab Uddin Hassan, Md Amir Hossain, Md Rezaul Karim, Abdullah Abu Sayeed, Stannie van den Ende, Sujat Pal, A. S.M. Zahed, Wahid Rahman, Rifat Karnain, Rezina Islam, Dung Thi Ngoc Tran, Tuyen Thanh Ha, Anh Hong Pham, James I. Campbell, H. Rogier van Doorn, Richard J. Maude, Tom van der Poll, W. Joost Wiersinga, Nicholas P.J. Day, Stephen Baker, Arjen M. Dondorp, Christopher M. Parry, Md Abul Faiz A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh. BMC Infectious Diseases. Vol.16, No.1 (2016). doi:10.1186/s12879-016-1886-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41047
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A prospective study of the importance of enteric fever as a cause of non-malarial febrile illness in patients admitted to Chittagong Medical College Hospital, Bangladesh
Author(s)
Rapeephan R. Maude
Aniruddha Ghose
Rasheda Samad
Hanna K. de Jong
Masako Fukushima
Lalith Wijedoru
Mahtab Uddin Hassan
Md Amir Hossain
Md Rezaul Karim
Abdullah Abu Sayeed
Stannie van den Ende
Sujat Pal
A. S.M. Zahed
Wahid Rahman
Rifat Karnain
Rezina Islam
Dung Thi Ngoc Tran
Tuyen Thanh Ha
Anh Hong Pham
James I. Campbell
H. Rogier van Doorn
Richard J. Maude
Tom van der Poll
W. Joost Wiersinga
Nicholas P.J. Day
Stephen Baker
Arjen M. Dondorp
Christopher M. Parry
Md Abul Faiz
Aniruddha Ghose
Rasheda Samad
Hanna K. de Jong
Masako Fukushima
Lalith Wijedoru
Mahtab Uddin Hassan
Md Amir Hossain
Md Rezaul Karim
Abdullah Abu Sayeed
Stannie van den Ende
Sujat Pal
A. S.M. Zahed
Wahid Rahman
Rifat Karnain
Rezina Islam
Dung Thi Ngoc Tran
Tuyen Thanh Ha
Anh Hong Pham
James I. Campbell
H. Rogier van Doorn
Richard J. Maude
Tom van der Poll
W. Joost Wiersinga
Nicholas P.J. Day
Stephen Baker
Arjen M. Dondorp
Christopher M. Parry
Md Abul Faiz
Abstract
© 2016 The Author(s). Background: Fever is a common cause of hospital admission in Bangladesh but causative agents, other than malaria, are not routinely investigated. Enteric fever is thought to be common. Methods: Adults and children admitted to Chittagong Medical College Hospital with a temperature of ≥38.0 °C were investigated using a blood smear for malaria, a blood culture, real-time PCR to detect Salmonella Typhi, S. Paratyphi A and other pathogens in blood and CSF and an NS1 antigen dengue ELISA. Results: We enrolled 300 febrile patients with a negative malaria smear between January and June 2012: 156 children (aged ≤15 years) and 144 adults with a median (interquartile range) age of 13 (5-31) years and median (IQR) illness duration before admission of five (2-8) days. Clinical enteric fever was diagnosed in 52 patients (17.3 %), lower respiratory tract infection in 48 (16.0 %), non-specific febrile illness in 48 (16.0 %), a CNS infection in 37 patients (12.3 %), urinary sepsis in 23 patients (7.7 %), an upper respiratory tract infection in 21 patients (7.0 %), and diarrhea or dysentery in 21 patients (7.0 %). Malaria was still suspected in seven patients despite a negative microscopy test. S. Typhi was detected in blood by culture or PCR in 34 (11.3 %) of patients. Of note Rickettsia typhi and Orientia tsutsugamushi were detected by PCR in two and one patient respectively. Twenty-nine (9 %) patients died during their hospital admission (15/160 (9.4 %) of children and 14/144 (9.7 %) adults). Two of 52 (3.8 %) patients with enteric fever, 5/48 (10.4 %) patients with lower respiratory tract infections, and 12/37 (32.4 %) patients with CNS infection died. Conclusion: Enteric fever was confirmed in 11.3 % of patients admitted to this hospital in Bangladesh with non-malaria fever. Lower respiratory tract and CNS infections were also common. CNS infections in this location merit more detailed study due to the high mortality.