Publication:
Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

Issued Date

2016-04-01

Resource Type

Article

ISSN

19326203

DOI

10.1371/journal.pone.0153243

Other identifier(s)

2-s2.0-84963770998

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

PLoS ONE. Vol.11, No.4 (2016)

Suggested Citation

M. Katherine Charles, Mary Lou Lindegren, C. William Wester, Meridith Blevins, Timothy R. Sterling, Nguyen Thi Dung, Jean Claude Dusingize, Divine Avit-Edi, Nicolas Durier, Barbara Castelnuovo, Gertrude Nakigozi, Claudia P. Cortes, Marie Ballif, Lukas Fenner, Samuel Ajayi, Kathryn Anastos, Jules Bashi, William Bishai, Andrew Boulle, Paula Braitstein, Gabriela Carriquiry, Jane E. Carter, Peter Cegielski, Cleophas Chimbetete, Mary Ann Davies, Lameck Diero, Stephany Duda, Matthias Egger, Tanoh François Eboua, Adrian Gasser, Elvin Geng, Joachim Charles Gnokori, Laura Hardwicke, Christopher Hoffmann, Robin Huebner, Nzali Kancheya, S. Kiertiburanakul, Peter Kim, Diero Lameck, Valériane Leroy, Charlotte Lewden, Anna Mandalakas, Mhairi Maskew, Rosemary McKaig, Lynne Mofenson, Mireille Mpoudi-Etame, Benson Okwara, Sam Phiri, Wasana Prasitsuebsai, April Petit, Hans Prozesky, Stewart E. Reid, Lorna Renner, Gary Reubenson, Annette Sohn, Quynh Vo, Dana Walker, Firas Wehbe, Christian Wejse, Carolyn Williams, Robin Wood, Kara Wools-Kaloustian, Zhang Yao, Evy Yunihastuti, F. J. Zhang, H. X. Zhao, N. Han, T. P. Merati, D. N. Wirawan, F. Yuliana, R. Ditangco, E. Uy, R. Bantique, P. Phanuphak, K. Ruxrungtham, A. Avihingsanon, M. Khongphattanayothin, S. Sungkanuparph, N. Sanmeema, R. Chaiwarith, T. Sirisanthana, W. Kotarathititum, T. T. Pham, D. D. Cuong, H. L. Ha, V. K. Nguyen, V. H. Bui, T. D. Nguyen, A. H. Sohn, B. Petersen, D. A. Cooper Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries. PLoS ONE. Vol.11, No.4 (2016). doi:10.1371/journal.pone.0153243 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41048

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Title

Implementation of tuberculosis intensive case finding, isoniazid preventive therapy, and infection control ("Three I's") and HIV-tuberculosis service integration in lower income countries

Author(s)

M. Katherine Charles
 Mary Lou Lindegren
 C. William Wester
 Meridith Blevins
 Timothy R. Sterling
 Nguyen Thi Dung
 Jean Claude Dusingize
 Divine Avit-Edi
 Nicolas Durier
 Barbara Castelnuovo
 Gertrude Nakigozi
 Claudia P. Cortes
 Marie Ballif
 Lukas Fenner
 Samuel Ajayi
 Kathryn Anastos
 Jules Bashi
 William Bishai
 Andrew Boulle
 Paula Braitstein
 Gabriela Carriquiry
 Jane E. Carter
 Peter Cegielski
 Cleophas Chimbetete
 Mary Ann Davies
 Lameck Diero
 Stephany Duda
 Matthias Egger
 Tanoh François Eboua
 Adrian Gasser
 Elvin Geng
 Joachim Charles Gnokori
 Laura Hardwicke
 Christopher Hoffmann
 Robin Huebner
 Nzali Kancheya
 S. Kiertiburanakul
 Peter Kim
 Diero Lameck
 Valériane Leroy
 Charlotte Lewden
 Anna Mandalakas
 Mhairi Maskew
 Rosemary McKaig
 Lynne Mofenson
 Mireille Mpoudi-Etame
 Benson Okwara
 Sam Phiri
 Wasana Prasitsuebsai
 April Petit
 Hans Prozesky
 Stewart E. Reid
 Lorna Renner
 Gary Reubenson
 Annette Sohn
 Quynh Vo
 Dana Walker
 Firas Wehbe
 Christian Wejse
 Carolyn Williams
 Robin Wood
 Kara Wools-Kaloustian
 Zhang Yao
 Evy Yunihastuti
 F. J. Zhang
 H. X. Zhao
 N. Han
 T. P. Merati
 D. N. Wirawan
 F. Yuliana
 R. Ditangco
 E. Uy
 R. Bantique
 P. Phanuphak
 K. Ruxrungtham
 A. Avihingsanon
 M. Khongphattanayothin
 S. Sungkanuparph
 N. Sanmeema
 R. Chaiwarith
 T. Sirisanthana
 W. Kotarathititum
 T. T. Pham
 D. D. Cuong
 H. L. Ha
 V. K. Nguyen
 V. H. Bui
 T. D. Nguyen
 A. H. Sohn
 B. Petersen
 D. A. Cooper

Other Contributor(s)

Vanderbilt University School of Medicine
 National Hospital of Tropical Diseases
 Women's Equity in Access to Care and Treatment
 Centre MTCT-plus
 amfAR - The Foundation for AIDS Research
 Infectious Diseases Institute
 Rakai Health Sciences Program
 Facultad de Medicina de la Universidad de Chile
 Institut fur Sozial- und Praventivmedizin
 Swiss Tropical and Public Health Institute (Swiss TPH)
 Universitat Basel
 Beijing Ditan Hospital
 Universitas Udayana
 Gokila
 The HIV Netherlands Australia Thailand Research Collaboration
 Mahidol University
 Research Institute for Health Sciences
 Bach Mai Hospital
 University of New South Wales (UNSW) Australia
 Penang Hospital
 Khon Kaen University
 Albert Einstein College of Medicine of Yeshiva University
 Newlands Clinic
 Aurum Institute for Health Research
 Lighthouse Trust
 Tygerberg Hospital
 Universiteit Stellenbosch
 Desmond Tutu HIV Centre
 University of Cape Town
 CNHU Hubert Maga
 Centre Hospitalier Universitaire de Yopougon
 Korle Bu Hospital
 Bandim Health Project
 UATH
 null

Abstract

© 2016 Charles et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Setting: World Health Organization advocates for integration of HIV-tuberculosis (TB) services and recommends intensive case finding (ICF), isoniazid preventive therapy (IPT), and infection control ("Three I's") for TB prevention and control among persons living with HIV. Objective: To assess the implementation of the "Three I's" of TB-control at HIV treatment sites in lower income countries. Design: Survey conducted between March-July, 2012 at 47 sites in 26 countries: 6 (13%) Asia Pacific, 7 (15%), Caribbean, Central and South America, 5 (10%) Central Africa, 8 (17%) East Africa, 14 (30%) Southern Africa, and 7 (15%) West Africa. Results: ICF using symptom-based screening was performed at 38% of sites; 45% of sites used symptom-screening plus additional diagnostics. IPT at enrollment or ART initiation was implemented in only 17% of sites, with 9% of sites providing IPT to tuberculin-skin-test positive patients. Infection control measures varied: 62% of sites separated smear-positive patients, and healthcare workers used masks at 57% of sites. Only 12 (26%) sites integrated HIV-TB services. Integration was not associated with implementation of TB prevention measures except for IPT provision at enrollment (42% integrated vs. 9% nonintegrated; p = 0.03). Conclusions: Implementation of TB screening, IPT provision, and infection control measures was low and variable across regional HIV treatment sites, regardless of integration status.

Keyword(s)

Agricultural and Biological Sciences
 Biochemistry, Genetics and Molecular Biology

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/41048

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Scopus 2016-2017