Publication: Comparative genome analysis between Southeast Asian and South American Zika viruses
Issued Date
2016-11-01
Resource Type
ISSN
19957645
Other identifier(s)
2-s2.0-84997080042
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Tropical Medicine. Vol.9, No.11 (2016), 1048-1054
Suggested Citation
Theerarat Kochakarn, Namfon Kotanan, Krittikorn Kümpornsin, Duangkamon Loesbanluechai, Monta Thammasatta, Prasert Auewarakul, Prapon Wilairat, Thanat Chookajorn Comparative genome analysis between Southeast Asian and South American Zika viruses. Asian Pacific Journal of Tropical Medicine. Vol.9, No.11 (2016), 1048-1054. doi:10.1016/j.apjtm.2016.10.002 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/41051
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Comparative genome analysis between Southeast Asian and South American Zika viruses
Abstract
© 2016 Hainan Medical University Objective To understand the cause for the differences between potentially mild Southeast Asian and the more pathogenic ZIKV in South America. Methods A comparative genomic analysis was performed to determine putative causations stemming from ZIKV. Results Phylogenetic analyses integrating geographical and time factors revealed that Southeast Asian ZIKV might not be the direct source of South American outbreaks as previously speculated. Amino acid residues unique to South American ZIKV isolates at the envelope, pr and NS1 proteins are listed and shown in the structural context. These unique residues on external viral proteins are not found in Southeast Asian ZIKV and could be responsible for the ongoing outbreak either via an intrinsic property of the virus or interactions with human immunity. Only a selected few primer/probe sets currently in clinical use were identified of being capable of detecting ZIKV strains worldwide. The envelope proteins of dengue virus (DENV) and ZIKV also showed a remarkable degree of similarity especially at the surface residues. Conclusions These findings may help explain the cross-reactivity of DENV antibodies to ZIKV. Thus, major caveats must be exercised in using existing diagnostic tools for ZIKV.