Publication: Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women
Issued Date
2017-01-01
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ISSN
19457197
0021972X
0021972X
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2-s2.0-85010617560
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Clinical Endocrinology and Metabolism. Vol.102, No.1 (2017), 23-32
Suggested Citation
Sara Stinca, Maria Andersson, Sandra Weibel, Isabelle Herter-Aeberli, Ralph Fingerhut, Sueppong Gowachirapant, Sonja Y. Hess, Nidhi Jaiswal, Tomislav Jukić, Zvonko Kusic, Ngoako Solomon Mabapa, Ashwini Kumar Nepal, Teofilo O.L. San Luis, Jia Qing Zhen, Michael Bruce Zimmermann Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women. Journal of Clinical Endocrinology and Metabolism. Vol.102, No.1 (2017), 23-32. doi:10.1210/jc.2016-2829 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42100
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Title
Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women
Other Contributor(s)
ETH Zurich
Kinderspital Zürich
Mahidol University
University of California, Davis
St. John's National Academy Of Health Sciences India
University of Zagreb School of Medicine
University of Venda for Science and Technology
B P Koirala Institute of Health Sciences
Iodine Global Network (IGN)
Shanxi Institute for Endemic Disease Prevention and Treatment
Kinderspital Zürich
Mahidol University
University of California, Davis
St. John's National Academy Of Health Sciences India
University of Zagreb School of Medicine
University of Venda for Science and Technology
B P Koirala Institute of Health Sciences
Iodine Global Network (IGN)
Shanxi Institute for Endemic Disease Prevention and Treatment
Abstract
© 2017 by the Endocrine Society. Context: Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies. Objectives: Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status. Design, Setting, and Participants: Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake. Main Outcome Measures: We measured the urinary iodine concentration and DBS thyroidstimulating hormone, total thyroxin, Tg, and TgAb. Results: In the reference population, the median DBS-Tg was 9.2 μg/L (95% confidence interval, 8.7 to 9.8 mg/L) and was not significantly different among trimesters. The reference range was 0.3 to 43.5 mg/L. Over a range of iodine intake, the Tg concentrations were U-shaped. Within countries, the median DBS-Tg and the presence of elevated DBS-Tg did not differ significantly between all PW and PW who were TgAb-negative. Conclusions: A median DBS-Tg of ∼10 mg/L with ,3% of values ≥44 μg/L indicated population iodine sufficiency. Concurrent measurement of TgAb did not appear necessary to assess the population iodine status.