Publication: Dietary supplementation of Thai black rice bran extract and yeast beta-glucan protects the dextran sodium sulphate mediated colitis induced rat
Issued Date
2017-01-01
Resource Type
ISSN
20462069
Other identifier(s)
2-s2.0-85008689623
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
RSC Advances. Vol.7, No.1 (2017), 396-402
Suggested Citation
Noppawat Pengkumsri, Bhagavathi Sundaram Sivamaruthi, Sasithorn Sirilun, Prasit Suwannalert, Teerapat Rodboon, Chutinun Prasitpuriprecha, Sartjin Peerajan, Widawal Butrungrod, Chaiyavat Chaiyasut Dietary supplementation of Thai black rice bran extract and yeast beta-glucan protects the dextran sodium sulphate mediated colitis induced rat. RSC Advances. Vol.7, No.1 (2017), 396-402. doi:10.1039/c6ra25548e Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42169
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Dietary supplementation of Thai black rice bran extract and yeast beta-glucan protects the dextran sodium sulphate mediated colitis induced rat
Abstract
© The Royal Society of Chemistry. The present study was employed to evaluate the impact of black rice bran (BRB) extract, and yeast β-glucan (YBG) supplementation on a dextran sodium sulfate (DSS)-induced colitis rat model. Serum level antioxidant enzymes, cytokines, and histopathological changes were studied by spectrophotometric, ELISA, HPLC, and microscopic analysis. The preventive effect of RB + YBG combinational treatment for DSS-induced colitis in rat was greater than that of RB extract and YBG regarding serum antioxidant level. The elevated expression of the studied inflammatory cytokines (IL-6, IL-17, IFN-γ) was effectively more attenuated by RB + YBG combinational treatment than other tested interventions, which was accompanied by an increase in anti-inflammatory cytokines (IL-10, TGF-β). The histological study supported that RB + YBG supplementation improves the health status of DSS-induced colitis rats. The results suggested that the supplementation of RB + YBG was a potent alternative nutrient based therapeutic agent for colitis and to prevent the development of cancer.