Publication: Therapeutic Pulsed Ultrasound Promotes Revascularization and Functional Recovery of Rat Skeletal Muscle after Contusion Injury
Issued Date
2016-12-01
Resource Type
ISSN
1879291X
03015629
03015629
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2-s2.0-84994479830
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Mahidol University
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SCOPUS
Bibliographic Citation
Ultrasound in Medicine and Biology. Vol.42, No.12 (2016), 2938-2949
Suggested Citation
Areeya Chongsatientam, Tossaporn Yimlamai Therapeutic Pulsed Ultrasound Promotes Revascularization and Functional Recovery of Rat Skeletal Muscle after Contusion Injury. Ultrasound in Medicine and Biology. Vol.42, No.12 (2016), 2938-2949. doi:10.1016/j.ultrasmedbio.2016.08.004 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/42381
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Title
Therapeutic Pulsed Ultrasound Promotes Revascularization and Functional Recovery of Rat Skeletal Muscle after Contusion Injury
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Abstract
© 2016 World Federation for Ultrasound in Medicine & Biology The mechanism by which therapeutic pulsed ultrasound (TPU) promotes the repair of damaged gastrocnemius muscle was investigated. Male Wistar rats were divided into uninjured, sham-treated injured and TPU-treated injured (TPU) groups. Injury was induced by mass-drop technique. TPU was applied to the injured muscle for 5 min, daily, started at day 1 post-injury and continuing for 3, 7 and 14 d. For 3 d post-injury, a significant reduction in muscle force was observed in both the sham-treated injured and TPU groups. TPU treatment significantly increased recovery force of the injured muscle after day 7 post-injury. This effect of TPU is associated with increased centronucleated fibers and cross-sectional area, mRNA expression of the vascular endothelial growth factor and capillary density of the regenerated fibers, but not with mRNA expression of nitric oxide synthase. We conclude that TPU hastens muscle recovery, at least in part, by upregulating angiogenesis.