Publication:
DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

Issued Date

2018-01-01

Resource Type

Article

ISSN

14770520

DOI

10.1039/c7ob02860a

Other identifier(s)

2-s2.0-85040903440

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Organic and Biomolecular Chemistry. Vol.16, No.3 (2018), 424-432

Suggested Citation

Akkharaphong Thupyai, Chaleena Pimpasri, Sirilata Yotphan DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides. Organic and Biomolecular Chemistry. Vol.16, No.3 (2018), 424-432. doi:10.1039/c7ob02860a Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45275

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Title

DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides

Author(s)

Akkharaphong Thupyai
 Chaleena Pimpasri
 Sirilata Yotphan

Other Contributor(s)

Mahidol University

Abstract

© 2018 The Royal Society of Chemistry. A highly efficient protocol for a direct thiolation of N-substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(i) acetate, the C-S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.

Keyword(s)

Biochemistry, Genetics and Molecular Biology
 Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/45275

Collections

Scopus 2018