Publication: Secopaxilline A, an indole-diterpenoid derivative from an aciduric: Penicillium fungus, its identification and semisynthesis
Issued Date
2018-10-07
Resource Type
ISSN
20524129
20524110
20524110
Other identifier(s)
2-s2.0-85053920769
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Mahidol University
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SCOPUS
Bibliographic Citation
Organic Chemistry Frontiers. Vol.5, No.19 (2018), 2835-2839
Suggested Citation
Yaqin Fan, Yi Wang, Peng Fu, Arthit Chairoungdua, Pawinee Piyachaturawat, Weiming Zhu Secopaxilline A, an indole-diterpenoid derivative from an aciduric: Penicillium fungus, its identification and semisynthesis. Organic Chemistry Frontiers. Vol.5, No.19 (2018), 2835-2839. doi:10.1039/c8qo00756j Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45471
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Title
Secopaxilline A, an indole-diterpenoid derivative from an aciduric: Penicillium fungus, its identification and semisynthesis
Abstract
© 2018 the Partner Organisations. Secopaxilline A (1), a new meroditerpenoid derived from indole-diterpenoid by the oxidative cleavage of a carbon-nitrogen bond, was isolated from an aciduric fungus Penicillium camemberti OUCMDZ-1492. Its structure, including absolute configuration, was fully elucidated based on spectroscopic analysis and X-ray single crystal diffraction. Secopaxilline A is the first example of indole-diterpenoid derivatives possessing a carbon-nitrogen bond cleavage skeleton. It was synthesized from paxilline with a 45% overall yield. The one-pot synthesis of the biosynthetic precursor, deacetylsecopaxilline A (4), from paxilline was also developed.