Publication: Accuracy of childhood asthma control test among thai childhood asthma patients
Issued Date
2018-09-01
Resource Type
ISSN
22288694
0125877X
0125877X
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2-s2.0-85054455770
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Mahidol University
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SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology. Vol.36, No.3 (2018), 152-158
Suggested Citation
Sirasuda Sommanus, Chalerat Direkwattanachai, Saranath Lawpoolsri, Raweerat Sitcharungsi Accuracy of childhood asthma control test among thai childhood asthma patients. Asian Pacific Journal of Allergy and Immunology. Vol.36, No.3 (2018), 152-158. doi:10.12932/AP-300517-0094 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/45976
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Title
Accuracy of childhood asthma control test among thai childhood asthma patients
Abstract
© 2018, Allergy and Immunology Society of Thailand. All rights reserved. Background: The Childhood Asthma Control Test (C-ACT) was developed to assess asthma control in children wowide. A self-administered questionnaire for children translated into Thai language was used. Objective: To validate the C-ACT cut-points for evaluating the level of asthma control among Thai children, using tGlobal Initiative for Asthma (GINA) guideline as a gold standard. Methods: C-ACT score, FEV1 and assessment of level of asthma control were recorded at baseline, 3-month, 6-month, and 1-year visits among children with asthma. Receiver operating characteristic (ROC) curves was used to determine the area under the curve (AUC) of C-ACT score for determining the level of asthma control. Validity indicators were calculated at different C-ACT cut-points to determine those most appropriate for predicting controlled and uncontrolled asthma. Results: We enrolled 279 children, 64% males, with mean age 6.87 ± 2.4 years. C-ACT score was significantly correlated with FEV1 at 3-month, 6-month, and 1-year visits (p < 0.001). The AUC of C-ACT score compared with GINA score were above 80% at all visits. The suggested C-ACT score cut-point of controlled asthma was ≥ 23 (sensitivity 69.5%, specificity 73.3%, positive predictive value (PPV) 81.2%, negative predictive value (NPV) 63.8%); that of uncontrolled asthma was ≤ 18 (sensitivity 54.2%, specificity 96.9%, PPV 61.9%, NPV 95.7%). Conclusions: The Thai version of the C-ACT is an accurate, simple, and useful tool for assessing asthma control aThai children. The high AUC suggests that the Thai C-ACT is as good as the GINA guideline in predicting asthma colevel.