Publication:
Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: A multinational multicenter prospective observational study

Issued Date

2018-02-14

Resource Type

Article

ISSN

20520492

DOI

10.1186/s40560-018-0279-7

Other identifier(s)

2-s2.0-85042110251

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Journal of Intensive Care. Vol.6, No.1 (2018)

Suggested Citation

Khie Chen Lie, Chuen Yen Lau, Nguyen Van Vinh Chau, T. Eoin West, Direk Limmathurotsakul, Pratiwi Sudarmono, Abu Tholib Aman, Mansyur Arif, Armaji Kamaludi Syarif, Herman Kosasih, Muhammad Karyana, Tawee Chotpitayasunondh, Warunee Punpanich Vandepitte, Adiratha Boonyasiri, Keswadee Lapphra, Kulkanya Chokephaibulkit, Pinyo Rattanaumpawan, Visanu Thamlikitkul, Achara Laongnualpanich, Prapit Teparrakkul, Pramot Srisamang, Phan Huu Phuc, Le Thanh Hai, Nguyen Van Kinh, Bui Duc Phu, Nguyen Thanh Hung, Tang Chi Thuong, Ha Manh Tuan, Lam Minh Yen, Nguyen Van Vinh Chau, Janjira Thaipadungpanit, Stuart Blacksell, Nicholas Day, Claire Ling, Guy Thwaites, Heiman Wertheim, Le Van Tan, Motiur Rahman, H. Rogier van Doorn Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: A multinational multicenter prospective observational study. Journal of Intensive Care. Vol.6, No.1 (2018). doi:10.1186/s40560-018-0279-7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/46945

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: A multinational multicenter prospective observational study

Author(s)

Khie Chen Lie
 Chuen Yen Lau
 Nguyen Van Vinh Chau
 T. Eoin West
 Direk Limmathurotsakul
 Pratiwi Sudarmono
 Abu Tholib Aman
 Mansyur Arif
 Armaji Kamaludi Syarif
 Herman Kosasih
 Muhammad Karyana
 Tawee Chotpitayasunondh
 Warunee Punpanich Vandepitte
 Adiratha Boonyasiri
 Keswadee Lapphra
 Kulkanya Chokephaibulkit
 Pinyo Rattanaumpawan
 Visanu Thamlikitkul
 Achara Laongnualpanich
 Prapit Teparrakkul
 Pramot Srisamang
 Phan Huu Phuc
 Le Thanh Hai
 Nguyen Van Kinh
 Bui Duc Phu
 Nguyen Thanh Hung
 Tang Chi Thuong
 Ha Manh Tuan
 Lam Minh Yen
 Nguyen Van Vinh Chau
 Janjira Thaipadungpanit
 Stuart Blacksell
 Nicholas Day
 Claire Ling
 Guy Thwaites
 Heiman Wertheim
 Le Van Tan
 Motiur Rahman
 H. Rogier van Doorn

Other Contributor(s)

Sappasitthiprasong Hospital
 Badan Penelitian Dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia
 University of Indonesia, RSUPN Dr. Cipto Mangunkusumo
 UCL
 National Institute of Allergy and Infectious Diseases
 University of Washington, Seattle
 Mahidol University
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Queen Sirikit National Institute of Child Health
 Nuffield Department of Clinical Medicine
 Oxford University Clinical Research Unit
 Hue Central Hospital
 National Hospital of Peadiatrics
 Wahidin Soedirohusodo Hospital
 Shoklo Malaria Research Unit
 Children's Hospital 2
 Children's Hospital 1
 Sardjito Hospital
 National Hospital of Tropical Diseases
 Chiangrai Prachanukroh Hospital
 Oxford University Clinical Research Unit

Abstract

© 2018 The Author(s). Background: Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods: We prospectively recruited hospitalized adults within 24 h of admission with community-acquired infection at nine public hospitals in Indonesia (n=3), Thailand (n=3), and Vietnam (n=3). In patients with organ dysfunction (total SOFA score ≥2), we analyzed sepsis management and outcomes and evaluated mortality prediction of the SOFA scores. Organ failure was defined as the maximum SOFA score ≥3 for an individual organ system. Results: From December 2013 to December 2015, 454 adult patients presenting with community-acquired sepsis due to diverse etiologies were enrolled. Compliance with sepsis bundles within 24 h of admission was low: broad-spectrum antibiotics in 76% (344/454), ≥1500 mL fluid in 50% of patients with hypotension or lactate ≥4 mmol/L (115/231), and adrenergic agents in 71% of patients with hypotension (135/191). Three hundred and fifty-five patients (78%) were managed outside of ICUs. Ninety-nine patients (22%) died. Total SOFA score on admission of those who subsequently died was significantly higher than that of those who survived (6.7 vs. 4.6, p<0.001). The number of organ failures showed a significant correlation with 28-day mortality, which ranged from 7% in patients without any organ failure to 47% in those with failure of at least four organs (p<0.001). The area under the receiver operating characteristic curve of the total SOFA score for discrimination of mortality was 0.68 (95% CI 0.62-0.74). Conclusions: Community-acquired sepsis in Southeast Asia due to a variety of pathogens is usually managed outside the ICU and with poor compliance to sepsis bundles. In this population, calculation of SOFA scores is feasible and SOFA scores are associated with mortality.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/46945

Collections

Scopus 2018