Publication:
Rhodotorula infection in haematological patient: Risk factors and outcome

Issued Date

2018-01-01

ISSN

14390507
09337407

DOI

10.1111/myc.12875

Other identifier(s)

2-s2.0-85059272598

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Mycoses. (2018)

Suggested Citation

Leonardo Potenza, Maria N. Chitasombat, Nikolay Klimko, Francesca Bettelli, Giulia Dragonetti, Maria Ilaria Del Principe, Marcio Nucci, Alessandro Busca, Nicola Fracchiolla, Mariarita Sciumè, Angelica Spolzino, Mario Delia, Valentina Mancini, Gian Paolo Nadali, Michela Dargenio, Olga Shadrivova, Federico Bacchelli, Franco Aversa, Maurizio Sanguinetti, Mario Luppi, Dimitrios P. Kontoyiannis, Livio Pagano Rhodotorula infection in haematological patient: Risk factors and outcome. Mycoses. (2018). doi:10.1111/myc.12875 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/47249

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Title

Rhodotorula infection in haematological patient: Risk factors and outcome

Author(s)

Leonardo Potenza
 Maria N. Chitasombat
 Nikolay Klimko
 Francesca Bettelli
 Giulia Dragonetti
 Maria Ilaria Del Principe
 Marcio Nucci
 Alessandro Busca
 Nicola Fracchiolla
 Mariarita Sciumè
 Angelica Spolzino
 Mario Delia
 Valentina Mancini
 Gian Paolo Nadali
 Michela Dargenio
 Olga Shadrivova
 Federico Bacchelli
 Franco Aversa
 Maurizio Sanguinetti
 Mario Luppi
 Dimitrios P. Kontoyiannis
 Livio Pagano

Other Contributor(s)

Azienda Ospedaliera - Universitaria Città della Salute e della Scienza di Torino
 Ospedale Vito Fazzi
 Fondazione Policlinico Universitario Agostino Gemelli IRCCS Università Cattolica del Sacro Cuore
 Università degli Studi di Verona
 Università degli Studi di Roma Tor Vergata
 Università degli Studi di Bari
 Azienda Ospedaliero - Universitaria di Modena Policlinico
 North-Western State Medical University named after I.I. Mechnikov
 Faculty of Medicine, Ramathibodi Hospital, Mahidol University
 Ospedale Niguarda, Milan
 University of Texas MD Anderson Cancer Center
 Ospedale Maggiore Policlinico Milano
 Università degli Studi di Parma
 Università degli Studi di Modena e Reggio Emilia
 Universidade Federal do Rio de Janeiro

Abstract

© 2018 Blackwell Verlag GmbH Background: Rhodotorula spp are uncommon yeasts able to cause infections with high mortality rates. Rhodotorula infections have been associated with the presence of central venous catheter (CVC), immunosuppression, exposure to antifungals and the presence of either solid or haematologic malignancies. However, in this latter setting, only a few cases have so far been reported. Objectives: We have conducted a survey for Rhodotorula infections in haematologic patients. Methods: Patients’ clinical and microbiological data were collected and correlated to the outcome. Results: A total of 27 cases were detected from 13 tertiary care hospitals. About 78% and 89% of patients had acute leukaemia and CVC. About 70% of patients were exposed to prophylaxis with azoles, mainly posaconazole (37%), 59% were severely neutropenic and 37% underwent allogeneic stem cell transplantation (alloSCT). The most frequent treatments were liposomal amphotericin B (L-AmB) and CVC removal in 17 and 16 patients, respectively. One month post-diagnosis, mortality was 26% and was associated with the presence of mucositis (P = 0.034). Conclusions: Our study shows that Rhodotorula spp should be considered as aetiologic agents of breakthrough infections in acute leukaemia patients with a CVC, mucositis, who receive prophylaxis with azoles, including posaconazole, and/or undergo alloSCT. Prompt measures, such as L-AmB administration and CVC removal, should be carried out to avoid the high mortality risk of Rhodotorula infections.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/47249

Collections

Scopus 2018