Folic acid-conjugated nanoparticles for targeted delivery to cancer cells
Issued Date
2019
Resource Type
Language
eng
Rights
Mahidol University
Rights Holder(s)
Faculty of Pharmacy Mahidol University
Suggested Citation
Varaporn Buraphacheep Junyaprasert, Varaporn B. Junyaprasert, วราภรณ์ จรรยาประเสริฐ (2019). Folic acid-conjugated nanoparticles for targeted delivery to cancer cells. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49476
Title
Folic acid-conjugated nanoparticles for targeted delivery to cancer cells
Other Contributor(s)
Abstract
Precise delivery of therapeutics to cancer cells is one of the greatest challenges in cancer
therapy. Nanoparticles are potential carriers to deliver drugs into tumor cells with minimum
drug leakage into normal cells. Conjugation of nanoparticles with ligands of cancer specific
molecules such as folate, transferrin, hyaluronic acid, antibodies, peptides, aptamers and
polysaccharides increase more specific drug targeting to cancer cells. Folic acid (FOL) is one
of the most widely used targeting ligands for anticancer drugs due to its specificity and high
binding affinity to the cancer cells. It provides additional advantages including ease of
modification, good stability upon storage and low cost. Folic acid receptor is overexpressed on
several cancer cell surfaces including ovarian, breast, lung, kidney, colorectal and brain
cancers. Many studies demonstrate that FOL-decorated nanoparticles can improve efficacy and
safety of anticancer drugs. In our recent studies, we found that the decoration of FOLconjugated
polycaprolactone (PCL) and FOL-conjugated tocopheryl polyethylene glycol 1000
succinate (TPGS) onto methrotexate-conjugated PCL nanoparticles potentiated cytotoxicity
and cellular uptake efficiency to folate receptor-expressed MCF-7 breast cancer cells.
Description
The 1st Pharmaceutical Sciences Asia Conference 2019 Theme : Pharmaceutical Sciences toward Health Innovation in the Disruptive Era. Bangkok Midtown Hotel, Thailand. August 22, 2019, page 8-9