Publication:
Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: Insights from the NeoAMR network

Issued Date

2020-01-01

Resource Type

Article

ISSN

14682044
00039888

DOI

10.1136/archdischild-2019-316816

Other identifier(s)

2-s2.0-85071514890

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Archives of Disease in Childhood. Vol.105, No.1 (2020), 26-31

Suggested Citation

Grace Li, Julia Anna Bielicki, A. S.M.Nawshad Uddin Ahmed, Mohammad Shahidul Islam, Eitan Naaman Berezin, Clery B. Gallacci, Ruth Guinsburg, Carlos Eduardo Da Silva Figueiredo, Rosilene Santarone Vieira, Andre Ricardo Silva, Cristiane Teixeira, Paul Turner, Ladin Nhan, Jaime Orrego, Paola Marsela Pérez, Lifeng Qi, Vassiliki Papaevangelou, Pinelope Triantafyllidou, Elias Iosifidis, Emmanuel Roilides, Kosmas Sarafidis, Dasaratha Ramaiah Jinka, Raghuprakash Reddy Nayakanti, Praveen Kumar, Vikas Gautam, Vinayagam Prakash, Arasar Seeralar, Srinivas Murki, Hemasree Kandraju, Sanjeev Singh, Anil Kumar, Leslie Lewis, Jayashree Pukayastha, Sushma Nangia, K. N. Yogesha, Suman Chaurasia, Harish Chellani, Stephen Obaro, Angela Dramowski, Adrie Bekker, Andrew Whitelaw, Reenu Thomas, Sithembiso Christopher Velaphi, Daynia Elizabeth Ballot, Trusha Nana, Gary Reubenson, Joy Fredericks, Suvaporn Anugulruengkitt, Anongnart Sirisub, Pimol Wong, Sorasak Lochindarat, Suppawat Boonkasidecha, Kanchana Preedisripipat, Tim R. Cressey, Pongsatorn Paopongsawan, Pagakrong Lumbiganon, Dounghatai Pongpanut, Pra Ornsuda Sukrakanchana, Philippa Musoke, Linus Olson, Mattias Larsson, Paul T. Heath, Michael Sharland Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: Insights from the NeoAMR network. Archives of Disease in Childhood. Vol.105, No.1 (2020), 26-31. doi:10.1136/archdischild-2019-316816 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/49678

Research Projects

Organizational Units

Authors

Journal Issue

Thesis

Title

Towards understanding global patterns of antimicrobial use and resistance in neonatal sepsis: Insights from the NeoAMR network

Author(s)

Grace Li
 Julia Anna Bielicki
 A. S.M.Nawshad Uddin Ahmed
 Mohammad Shahidul Islam
 Eitan Naaman Berezin
 Clery B. Gallacci
 Ruth Guinsburg
 Carlos Eduardo Da Silva Figueiredo
 Rosilene Santarone Vieira
 Andre Ricardo Silva
 Cristiane Teixeira
 Paul Turner
 Ladin Nhan
 Jaime Orrego
 Paola Marsela Pérez
 Lifeng Qi
 Vassiliki Papaevangelou
 Pinelope Triantafyllidou
 Elias Iosifidis
 Emmanuel Roilides
 Kosmas Sarafidis
 Dasaratha Ramaiah Jinka
 Raghuprakash Reddy Nayakanti
 Praveen Kumar
 Vikas Gautam
 Vinayagam Prakash
 Arasar Seeralar
 Srinivas Murki
 Hemasree Kandraju
 Sanjeev Singh
 Anil Kumar
 Leslie Lewis
 Jayashree Pukayastha
 Sushma Nangia
 K. N. Yogesha
 Suman Chaurasia
 Harish Chellani
 Stephen Obaro
 Angela Dramowski
 Adrie Bekker
 Andrew Whitelaw
 Reenu Thomas
 Sithembiso Christopher Velaphi
 Daynia Elizabeth Ballot
 Trusha Nana
 Gary Reubenson
 Joy Fredericks
 Suvaporn Anugulruengkitt
 Anongnart Sirisub
 Pimol Wong
 Sorasak Lochindarat
 Suppawat Boonkasidecha
 Kanchana Preedisripipat
 Tim R. Cressey
 Pongsatorn Paopongsawan
 Pagakrong Lumbiganon
 Dounghatai Pongpanut
 Pra Ornsuda Sukrakanchana
 Philippa Musoke
 Linus Olson
 Mattias Larsson
 Paul T. Heath
 Michael Sharland

Other Contributor(s)

Shenzhen Children's Hospital
 Fundación Valle del Lili
 Mulago Hospital
 Makerere University
 Government General Hospital Chennai
 St George's University of London
 National and Kapodistrian University of Athens
 Chulalongkorn University
 Dhaka Shishu Hospital
 Lady Hardinge Medical College
 Fundacao Oswaldo Cruz
 Khon Kaen University
 VMMC & Safdarjang Hospital
 University of Witwatersrand
 Kasturba Medical College, Manipal
 Attikon University Hospital
 Aristotle University of Thessaloniki
 Universidade Federal de Sao Paulo
 Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo
 Karolinska Institutet
 Faculty of Medicine, Siriraj Hospital, Mahidol University
 Tygerberg Hospital
 Queen Sirikit National Institute of Child Health
 All India Institute of Medical Sciences, New Delhi
 Amrita Institute of Medical Sciences India
 Universitäts-Kinderspital beider Basel
 Universidade Federal Fluminense
 Universiteit Stellenbosch
 Postgraduate Institute of Medical Education & Research, Chandigarh
 International Foundation Against Infectious Disease in Nigeria
 Rural Development Trust Hospital
 Cambodia Oxford Medical Research Unit
 Phayao Hospital
 Chiangrai Prachanukroh Hospital
 Fernandez Hospital
 Angkor Hospital for Children
 Prontobaby Hospital da Criança

Abstract

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Objective To gain an understanding of the variation in available resources and clinical practices between neonatal units (NNUs) in the low-income and middle-income country (LMIC) setting to inform the design of an observational study on the burden of unit-level antimicrobial resistance (AMR). Design A web-based survey using a REDCap database was circulated to NNUs participating in the Neonatal AMR research network. The survey included questions about NNU funding structure, size, admission rates, access to supportive therapies, empirical antimicrobial guidelines and period prevalence of neonatal blood culture isolates and their resistance patterns. Setting 39 NNUs from 12 countries. Patients Any neonate admitted to one of the participating NNUs. Interventions This was an observational cohort study. Results The number of live births per unit ranged from 513 to 27 700 over the 12-month study period, with the number of neonatal cots ranging from 12 to 110. The proportion of preterm admissions <32 weeks ranged from 0% to 19%, and the majority of units (26/39, 66%) use Essential Medicines List 'Access' antimicrobials as their first-line treatment in neonatal sepsis. Cephalosporin resistance rates in Gram-negative isolates ranged from 26% to 84%, and carbapenem resistance rates ranged from 0% to 81%. Glycopeptide resistance rates among Gram-positive isolates ranged from 0% to 45%. Conclusion AMR is already a significant issue in NNUs worldwide. The apparent burden of AMR in a given NNU in the LMIC setting can be influenced by a range of factors which will vary substantially between NNUs. These variations must be considered when designing interventions to improve neonatal mortality globally.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/49678

Collections

Scopus 2020