Publication: Characterization of FOXO acetylation
Issued Date
2019-01-01
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ISSN
10643745
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2-s2.0-85056409569
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Mahidol University
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SCOPUS
Bibliographic Citation
Methods in Molecular Biology. Vol.1890, (2019), 77-90
Suggested Citation
Shang Yao, Zimam Mahmud, Nikoleta Sachini, Sathid Aimjongjun, Paula Saavedra-García, Eric W.F. Lam Characterization of FOXO acetylation. Methods in Molecular Biology. Vol.1890, (2019), 77-90. doi:10.1007/978-1-4939-8900-3_7 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/50382
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Title
Characterization of FOXO acetylation
Abstract
© 2019, Springer Science+Business Media, LLC, part of Springer Nature. FOXO3 is a tumor suppressor that orchestrates the expression of genes that regulate cell cycle progression, apoptosis, metabolism, oxidative stress, and other important cellular processes. Its inactivation is closely associated with tumorigenesis and cancer progression. On the other hand, sirtuin proteins have been demonstrated to be able to deacetylate, thus causing FOXO3 inactivation at the posttranslational level. Therefore, targeting sirtuin proteins renders new avenues for breast cancer treatment. Here, we describe three procedures for studying FOXO3 posttranslational modifications controlled by sirtuin proteins in cancer cells.