Publication: Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients
Issued Date
2019-08-01
Resource Type
ISSN
18735967
13866532
13866532
Other identifier(s)
2-s2.0-85068264479
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Virology. Vol.117, (2019), 103-108
Suggested Citation
Benjamas Chuaychoo, Sopita Ngamwongwan, Bualan Kaewnaphan, Niracha Athipanyasilp, N. Horthongkham, Wannee Kantakamalakul, Nisa Muangman Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients. Journal of Clinical Virology. Vol.117, (2019), 103-108. doi:10.1016/j.jcv.2019.07.001 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51036
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Clinical manifestations and outcomes of respiratory syncytial virus infection in adult hospitalized patients
Other Contributor(s)
Abstract
© 2019 Background: Respiratory syncytial virus (RSV) is an important virus found in adult hospitalized patients. Objectives: To study the clinical outcomes of hospitalized patients aged ≥ 15 years and diagnosed with RSV infection. Study design: Both retrospective and prospective cohort studies were conducted at a university hospital between May 2014 and December 2015. Results: RSV was detected in 86 of 1562(5.5%) adult hospitalized patients suspected of respiratory viral infection. Sixty-nine patients were included in the study. RSV was detected by RT-PCR (82.6%), IFA (10.1%), and both RT-PCR and IFA (7.3%). Most patients (87.0%) were aged ≥ 50 years. Cardiovascular diseases, pulmonary diseases, immunocompromised hosts, and diabetes were the major comorbidities. The common manifestations were cough (92.8%), dyspnea (91.3%), sputum production (87.0%), tachypnea (75.4%), wheezing (73.9%), and fever (71.0%). Fifty- five patients (79.7%) were diagnosed with pneumonia. Hypoxemia (SpO2 ≤ 92%) was found in 53.6% patients. Twenty-five of 69(36.2%) patients developed respiratory failure and required ventilatory support. Cardiovascular complications were found in 24.6% of patients. Congestive heart failure, acute myocardial infarction (MI), new atrial fibrillation, and supraventricular tachycardia were found in 9(13.0%), 7(10.1%), 4(5.8%), and 3(4.3%) of 69 patients, respectively. Overall mortality was 15.9%. Pneumonia (81.8%) and acute MI (18.2%) were the major causes of death. Conclusions: Most adult hospitalized patients with RSV infection were of advanced age and had comorbidities. Cardiopulmonary complications were the major causes of death. Management and prevention of RSV infection in these vulnerable groups are necessary.