Publication: Severe anaphylaxis after pelvic examination: A case report of dual latex and chlorhexidine allergies
Issued Date
2019-03-29
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ISSN
17101492
17101484
17101484
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2-s2.0-85063734915
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Mahidol University
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SCOPUS
Bibliographic Citation
Allergy, Asthma and Clinical Immunology. Vol.15, No.1 (2019)
Suggested Citation
Mongkhon Sompornrattanaphan, Piyawut Kreetapirom, Yuttana Srinoulprasert, Duangjit Kanistanon, Anchalika Klinniyom, Chamard Wongsa, Torpong Thongngarm Severe anaphylaxis after pelvic examination: A case report of dual latex and chlorhexidine allergies. Allergy, Asthma and Clinical Immunology. Vol.15, No.1 (2019). doi:10.1186/s13223-019-0335-4 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51086
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Title
Severe anaphylaxis after pelvic examination: A case report of dual latex and chlorhexidine allergies
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Abstract
© 2019 The Author(s). Background: Natural rubber latex and chlorhexidine have previously been identified as causative substances in perioperative anaphylaxis. A pelvic examinations is generally considered noninvasive, however, this procedure is rarely associated with severe allergic reactions. We reported a rare case of dual latex and chlorhexidine allergies which caused anaphylaxis after pelvic examination in a woman with a history of latex-related fruits allergy. Case presentation: A 54-year-old woman had severe anaphylaxis after a pelvic examination due to dual latex and chlorhexidine (CHX) allergies. The gynecologist used CHX for the vaginal preparation and wore latex-containing gloves with lubricating gel during the examination. In vivo and in vitro tests revealed CHX sensitization by a positive skin prick test to chlorhexidine at a very low concentration (0.002 mg/mL), and a positive basophil activation test to CHX. Latex allergy was confirmed by a positive specific IgE to latex and a positive glove-use test at 20 min. An analysis of specific IgE to latex component revealed positive results for Hev b 1, 5, 6.02, and 11. As she also had a past history of fruit allergy, prick-to-prick testing with latex-related fruits was performed. The results were positive for avocado, banana, jackfruit, kiwi, and longan. Conclusions: Concomitant mucosal exposure of both natural rubber latex and CHX in highly sensitized patients during pelvic examinations can lead to severe anaphylaxis. Pre-procedural screening for an allergy to latex or CHX, or to any other allergen, should be performed in patients where there is suspicion of a specific allergy due to a previous allergic reaction. Increased awareness of these two allergens in all healthcare settings may improve patient safety.