Publication: Mechanisms of Vascular Calcification in Kidney Disease
Issued Date
2019-11-01
Resource Type
ISSN
15485609
15485595
15485595
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2-s2.0-85076103420
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Mahidol University
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SCOPUS
Bibliographic Citation
Advances in Chronic Kidney Disease. Vol.26, No.6 (2019), 417-426
Suggested Citation
Sinee Disthabanchong, Praopilad Srisuwarn Mechanisms of Vascular Calcification in Kidney Disease. Advances in Chronic Kidney Disease. Vol.26, No.6 (2019), 417-426. doi:10.1053/j.ackd.2019.08.014 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51322
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Title
Mechanisms of Vascular Calcification in Kidney Disease
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Abstract
© 2019 National Kidney Foundation, Inc. The increase in prevalence and severity of vascular calcification in chronic kidney disease is a result of complex interactions between changes in the vascular bed, mineral metabolites, and other uremic factors. Vascular calcification can occur in the intima and the media of arterial wall. Under permissive conditions, vascular smooth muscle cells (VSMCs) can transform to osteoblast-like phenotype. The membrane-bound vesicles released from transformed VSMCs and the apoptotic bodies derived from dying VSMCs serve as nucleating structures for calcium crystal formation. Alterations in the quality and the quantity of endogenous calcification inhibitors also give rise to an environment that potentiates calcification.