Publication: The extracts of astragalus membranaceus enhance chemosensitivity and reduce tumor indoleamine 2, 3-dioxygenase expression
Issued Date
2019-01-01
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ISSN
14491907
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2-s2.0-85072205417
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Medical Sciences. Vol.16, No.8 (2019), 1107-1115
Suggested Citation
Naphichaya Phacharapiyangkul, Li Hsien Wu, Wei Ya Lee, Yi Hsuan Kuo, Yueh Jung Wu, Huei Pu Liou, Yung En Tsai, Che Hsin Lee The extracts of astragalus membranaceus enhance chemosensitivity and reduce tumor indoleamine 2, 3-dioxygenase expression. International Journal of Medical Sciences. Vol.16, No.8 (2019), 1107-1115. doi:10.7150/ijms.33106 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/52364
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Title
The extracts of astragalus membranaceus enhance chemosensitivity and reduce tumor indoleamine 2, 3-dioxygenase expression
Abstract
© The author(s). Astragalus membranaceus has been shown to possess anti-inflammation and antitumor properties. Several studies have indicated that extracts of Astragalus membranaceus (PG2) have growth inhibitory effects on tumor. However, the effect of PG2 on enhancing the chemotherapy, modulating tumor immune escape and their mechanism of action is unknown and need further investigation. Connexin (Cx) 43 is ubiquitous in cells and involved in facilitating the passage of chemotherapeutic drugs to bystander tumor cells. The indoleamine 2, 3-dioxygenase (IDO) depletes tryptophan, reduces the active T cell number and destroys immune surveillance. Herein, we provide evidence that the treatment of PG2 induced Cx43 expression, decreases IDO expression and enhances the distribution of chemotherapeutic drug. However, the effects of combination therapy (PG2 plus cisplatin) in animal models significantly retarded tumor growth and prolonged the survival. We believe that the information provided in this study may aid in the design of future therapy of PG2, suggest suitable combinations with chemotherapies.