Publication: Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis
Issued Date
2020-02-18
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ISSN
2050084X
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2-s2.0-85081069101
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Mahidol University
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SCOPUS
Bibliographic Citation
eLife. Vol.9, (2020)
Suggested Citation
Wenn Chyau Lee, Bruce Russell, Radoslaw Mikolaj Sobota, Khairunnisa Ghaffar, Shanshan W. Howland, Zi Xin Wong, Alexander G. Maier, Dominique Dorin-Semblat, Subhra Biswas, Benoit Gamain, Yee Ling Lau, Benoit Malleret, Cindy Chu, François Nosten, Laurent Renia Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis. eLife. Vol.9, (2020). doi:10.7554/eLife.51546 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53584
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Title
Plasmodium-infected erythrocytes induce secretion of IGFBP7 to form type II rosettes and escape phagocytosis
Other Contributor(s)
A-Star, Singapore Immunology Network
Universite Paris-Saclay
University of Malaya
Yong Loo Lin School of Medicine
Agency for Science, Technology and Research, Singapore
A-Star, Institute of Molecular and Cell Biology
University of Otago
Institut National de la Transfusion Sanguine
Mahidol University
Australian National University
Nuffield Department of Clinical Medicine
Universite Paris-Saclay
University of Malaya
Yong Loo Lin School of Medicine
Agency for Science, Technology and Research, Singapore
A-Star, Institute of Molecular and Cell Biology
University of Otago
Institut National de la Transfusion Sanguine
Mahidol University
Australian National University
Nuffield Department of Clinical Medicine
Abstract
© 2020, Lee et al. In malaria, rosetting is described as a phenomenon where an infected erythrocyte (IRBC) is attached to uninfected erythrocytes (URBC). In some studies, rosetting has been associated with malaria pathogenesis. Here, we have identified a new type of rosetting. Using a step-by-step approach, we identified IGFBP7, a protein secreted by monocytes in response to parasite stimulation, as a rosette-stimulator for Plasmodium falciparum- and P. vivax-IRBC. IGFBP7-mediated rosette-stimulation was rapid yet reversible. Unlike type I rosetting that involves direct interaction of rosetting ligands on IRBC and receptors on URBC, the IGFBP7-mediated, type II rosetting requires two additional serum factors, namely von Willebrand factor and thrombospondin-1. These two factors interact with IGFBP7 to mediate rosette formation by the IRBC. Importantly, the IGFBP7-induced type II rosetting hampers phagocytosis of IRBC by host phagocytes.