Publication:
The release of the bromodomain ligand N,N-dimethylacetamide adds bioactivity to a resorbable guided bone regeneration membrane in a rabbit calvarial defect model

Issued Date

2020-02-01

Resource Type

Article

ISSN

19961944

DOI

10.3390/ma13030501

Other identifier(s)

2-s2.0-85079290883

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

Materials. Vol.13, No.3 (2020)

Suggested Citation

Barbara Siegenthaler, Chafik Ghayor, Nisarat Ruangsawasdi, Franz E. Weber The release of the bromodomain ligand N,N-dimethylacetamide adds bioactivity to a resorbable guided bone regeneration membrane in a rabbit calvarial defect model. Materials. Vol.13, No.3 (2020). doi:10.3390/ma13030501 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/53711

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Title

The release of the bromodomain ligand N,N-dimethylacetamide adds bioactivity to a resorbable guided bone regeneration membrane in a rabbit calvarial defect model

Author(s)

Barbara Siegenthaler
 Chafik Ghayor
 Nisarat Ruangsawasdi
 Franz E. Weber

Other Contributor(s)

Mahidol University
 University of Zurich

Abstract

© 2020 by the authors. N,N-Dimethylacetamide (DMA) is FDA approved as an excipient and is used as drug-delivery vehicle. Due to its amphipathic nature and diverse bioactivities, it appears to be a good combination of biodegradable poly-lactide-co-glycolide (PLGA)-based guided bone regeneration membranes. Here we show that the solvent DMA can be loaded to PLGA membranes by different regimes, leading to distinct release profiles, and enhancing the bone regeneration in vivo. Our results highlight the potential therapeutic benefits of DMA in guided bone regeneration procedures, in combination with biodegradable PLGA membranes.

Keyword(s)

Materials Science

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/53711

Collections

Scopus 2020