Publication:
Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of LAS VEGAS study

Issued Date

2020-04-02

Resource Type

Article

ISSN

14712253

DOI

10.1186/s12871-020-00988-x

Other identifier(s)

2-s2.0-85082895096

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

BMC Anesthesiology. Vol.20, No.1 (2020)

Suggested Citation

Chiara Robba, Sabrine N.T. Hemmes, Ary Serpa Neto, Thomas Bluth, Jaume Canet, Michael Hiesmayr, M. Wiersma Hollmann, Gary H. Mills, Marcos F. Vidal Melo, Christian Putensen, Samir Jaber, Werner Schmid, Paolo Severgnini, Hermann Wrigge, Denise Battaglini, Lorenzo Ball, Marcelo Gama De Abreu, Marcus J. Schultz, Paolo Pelosi, Wolfgang Kroell, Helfried Metzler, Gerd Struber, Thomas Wegscheider, Hans Gombotz, Michael Hiesmayr, Werner Schmid, Bernhard Urbanek, David Kahn, Mona Momeni, Audrey Pospiech, Fernande Lois, Patrice Forget, Irina Grosu, Jan Poelaert, Veerle Van Mossevelde, Marie Claire Van Malderen, Dimitri Dylst, Jeroen Van Melkebeek, Maud Beran, Stefan De Hert, Luc De Baerdemaeker, Bjorn Heyse, Jurgen Van Limmen, Piet Wyffels, Tom Jacobs, Nathalie Roels, Ann De Bruyne, Stijn Van De Velde, Brigitte Leva, Sandrine Damster, Benoit Plichon, Marina Juros-Zovko, Dejana Djonoviċ-Omanoviċ, Selma Pernar, Josip Zunic, Petar Miskovic, Antonio Zilic, Slavica Kvolik, Dubravka Ivic, Darija Azenic-Venzera, Sonja Skiljic, Hrvoje Vinkovic, Ivana Oputric, Kazimir Juricic, Vedran Frkovic, Jasminka Kopic, Ivan Mirkovic, Nenad Karanovic, Mladen Carev, Natasa Dropulic, Jadranka Pavicic Saric, Gorjana Erceg, Matea Bogdanovic Dvorscak, Branka Mazul-Sunko, Anna Marija Pavicic, Tanja Goranovic, Branka Maldini, Tomislav Radocaj, Zeljka Gavranovic, Inga Mladic-Batinica, Mirna Sehovic, Petr Stourac, Hana Harazim, Olga Smekalova, Martina Kosinova, Tomas Kolacek, Kamil Hudacek, Michal Drab, Jan Brujevic, Katerina Vitkova, Katerina Jirmanova, Ivana Volfova, Paula Dzurnakova, Katarina Liskova, Radovan Dudas, Radek Filipsky, Samir El Kafrawy, Hisham Hosny Abdelwahab, Tarek Metwally, Ahmed Abdel-Razek Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of LAS VEGAS study. BMC Anesthesiology. Vol.20, No.1 (2020). doi:10.1186/s12871-020-00988-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54608

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Title

Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of LAS VEGAS study

Author(s)

Chiara Robba
 Sabrine N.T. Hemmes
 Ary Serpa Neto
 Thomas Bluth
 Jaume Canet
 Michael Hiesmayr
 M. Wiersma Hollmann
 Gary H. Mills
 Marcos F. Vidal Melo
 Christian Putensen
 Samir Jaber
 Werner Schmid
 Paolo Severgnini
 Hermann Wrigge
 Denise Battaglini
 Lorenzo Ball
 Marcelo Gama De Abreu
 Marcus J. Schultz
 Paolo Pelosi
 Wolfgang Kroell
 Helfried Metzler
 Gerd Struber
 Thomas Wegscheider
 Hans Gombotz
 Michael Hiesmayr
 Werner Schmid
 Bernhard Urbanek
 David Kahn
 Mona Momeni
 Audrey Pospiech
 Fernande Lois
 Patrice Forget
 Irina Grosu
 Jan Poelaert
 Veerle Van Mossevelde
 Marie Claire Van Malderen
 Dimitri Dylst
 Jeroen Van Melkebeek
 Maud Beran
 Stefan De Hert
 Luc De Baerdemaeker
 Bjorn Heyse
 Jurgen Van Limmen
 Piet Wyffels
 Tom Jacobs
 Nathalie Roels
 Ann De Bruyne
 Stijn Van De Velde
 Brigitte Leva
 Sandrine Damster
 Benoit Plichon
 Marina Juros-Zovko
 Dejana Djonoviċ-Omanoviċ
 Selma Pernar
 Josip Zunic
 Petar Miskovic
 Antonio Zilic
 Slavica Kvolik
 Dubravka Ivic
 Darija Azenic-Venzera
 Sonja Skiljic
 Hrvoje Vinkovic
 Ivana Oputric
 Kazimir Juricic
 Vedran Frkovic
 Jasminka Kopic
 Ivan Mirkovic
 Nenad Karanovic
 Mladen Carev
 Natasa Dropulic
 Jadranka Pavicic Saric
 Gorjana Erceg
 Matea Bogdanovic Dvorscak
 Branka Mazul-Sunko
 Anna Marija Pavicic
 Tanja Goranovic
 Branka Maldini
 Tomislav Radocaj
 Zeljka Gavranovic
 Inga Mladic-Batinica
 Mirna Sehovic
 Petr Stourac
 Hana Harazim
 Olga Smekalova
 Martina Kosinova
 Tomas Kolacek
 Kamil Hudacek
 Michal Drab
 Jan Brujevic
 Katerina Vitkova
 Katerina Jirmanova
 Ivana Volfova
 Paula Dzurnakova
 Katarina Liskova
 Radovan Dudas
 Radek Filipsky
 Samir El Kafrawy
 Hisham Hosny Abdelwahab
 Tarek Metwally
 Ahmed Abdel-Razek

Other Contributor(s)

Ospedale Policlinico San Martino
 CHU Montpellier
 Universitäts-Klinikum Bonn und Medizinische Fakultät
 Massachusetts General Hospital
 Dresden University Faculty of Medicine and University Hospital Carl Gustav Carus
 Università degli Studi di Genova
 Hospital Israelita Albert Einstein
 Mahidol University
 Hospital Universitari de Bellvitge
 Medizinische Universitat Wien
 Universität Leipzig
 Università degli Studi dell'Insubria
 University of Sheffield
 Amsterdam UMC - University of Amsterdam

Abstract

© 2020 The Author(s). Background: Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods: Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into groups based on the type of surgery (brain and spine), the occurrence of PPCs and the assess respiratory risk in surgical patients in Catalonia (ARISCAT) score risk for PPCs. Results: Seven hundred eighty-four patients were included in the analysis; 408 patients (52%) underwent spine surgery and 376 patients (48%) brain surgery. Median tidal volume (VT) was 8 ml [Interquartile Range, IQR = 7.3-9] per predicted body weight; median positive end-expiratory pressure (PEEP) was 5 [3 to 5] cmH20. Planned recruitment manoeuvres were used in the 6.9% of patients. No differences in ventilator settings were found among the sub-groups. PPCs occurred in 81 patients (10.3%). Duration of anaesthesia (odds ratio, 1.295 [95% confidence interval 1.067 to 1.572]; p = 0.009) and higher age for the brain group (odds ratio, 0.000 [0.000 to 0.189]; p = 0.031), but not intraoperative ventilator settings were independently associated with development of PPCs. Conclusions: Neurosurgical patients are ventilated with low VT and low PEEP, while recruitment manoeuvres are seldom applied. Intraoperative ventilator settings are not associated with PPCs.

Keyword(s)

Medicine

Availability

URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/54608

Collections

Scopus 2020