Publication: Hypomethylation of Alu elements in post-menopausal women with osteoporosis
Accepted Date
2013-06-21
Issued Date
2013-08-21
Copyright Date
2013
Resource Type
Language
eng
ISSN
1932-6203 (electronic)
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Mahidol University
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PubMed Central
Bibliographic Citation
Jintaridth P, Tungtrongchitr R, Preutthipan S, Mutirangura A. Hypomethylation of Alu elements in post-menopausal women with osteoporosis. PLoS One. 2013 Aug 21;8(8):e70386.
Suggested Citation
Pornrutsami Jintaridth, พรรัสสามิ จินทาริด, Rungsunn Tungtrongchitr, รังสรรค์ ตั้งตรงจิตร, Sangchai Preutthipan, Apiwat Mutirangura Hypomethylation of Alu elements in post-menopausal women with osteoporosis. Jintaridth P, Tungtrongchitr R, Preutthipan S, Mutirangura A. Hypomethylation of Alu elements in post-menopausal women with osteoporosis. PLoS One. 2013 Aug 21;8(8):e70386.. doi:10.1371/journal.pone.0070386 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/748
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Title
Hypomethylation of Alu elements in post-menopausal women with osteoporosis
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Abstract
A decrease in genomic methylation commonly occurs in aging cells; however, whether this epigenetic modification leads to age-related phenotypes has not been evaluated. Alu elements are the major interspersed repetitive DNA elements in
humans that lose DNA methylation in aging individuals. Alu demethylation in blood
cells starts at approximately 40 years of age, and the degree of Alu hypomethylation increases with age. Bone mass is lost with aging, particularly in menopausal women with lower body mass. Consequently, osteoporosis is commonly
found in thin postmenopausal women. Here, we correlated the Alu methylation level
of blood cells with bone density in 323 postmenopausal women. Alu hypomethylation
was associated with advanced age and lower bone mass density, (P<0.05). The association between the Alu methylation level and bone mass was independent of age, body mass, and body fat, with an odds ratio [1] = 0.4316 (0.2087-0.8927).
Individuals of the same age with osteopenia, osteoporosis, and a high body mass
index have lower Alu methylation levels (P = 0.0005, 0.003, and ≤0.0001,
respectively). Finally, when comparing individuals with the same age and body
mass, Alu hypomethylation was observed in individuals with lower bone mass
(P<0.0001). In conclusion, there are positive correlations between Alu
hypomethylation in blood cells and several age-related phenotypes in bone and
body fat. Therefore, reduced global methylation may play a role in the systemic
senescence process. Further evaluation of Alu hypomethylation may clarify the
epigenetic regulation of osteoporosis in post-menopausal women.