Publication: Effect of vitamin e supplement on bone turnover markers in postmenopausal osteopenic women: A double-blind, randomized, placebo-controlled trial
Issued Date
2021-12-01
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ISSN
20726643
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2-s2.0-85119651714
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Mahidol University
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SCOPUS
Bibliographic Citation
Nutrients. Vol.13, No.12 (2021)
Suggested Citation
Sakda Arj Ong Vallibhakara, Katanyuta Nakpalat, Areepan Sophonsritsuk, Chananya Tantitham, Orawin Vallibhakara Effect of vitamin e supplement on bone turnover markers in postmenopausal osteopenic women: A double-blind, randomized, placebo-controlled trial. Nutrients. Vol.13, No.12 (2021). doi:10.3390/nu13124226 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75523
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Title
Effect of vitamin e supplement on bone turnover markers in postmenopausal osteopenic women: A double-blind, randomized, placebo-controlled trial
Abstract
Vitamin E is a strong anti-oxidative stress agent that affects the bone remodeling pro-cess. This study evaluates the effect of mixed-tocopherol supplements on bone remodeling in postmenopausal osteopenic women. A double-blinded, randomized, placebo-controlled trial study was designed to measure the effect of mixed-tocopherol on the bone turnover marker after 12 weeks of supplementation. All 52 osteopenic postmenopausal women were enrolled and allocated into two groups. The intervention group received mixed-tocopherol 400 IU/day, while the control group received placebo tablets. Fifty-two participants completed 12 weeks of follow-up. Under an intention-to-treat analysis, vitamin E produced a significant difference in the mean bone resorption marker (serum C-terminal telopeptide of type I collagen (CTX)) compared with the placebo group (−0.003 ± 0.09 and 0.121 ± 0.15, respectively (p < 0.001)). In the placebo group, the CTX had increased by 35.3% at 12 weeks of supplementation versus baseline (p < 0.001), while, in the vitamin E group, there was no significant change of bone resorption marker (p < 0.898). In conclusion, vitamin E (mixed-tocopherol) supplementation in postmenopausal osteopenic women may have a preventive effect on bone loss through antiresorptive activity.