Publication: Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa
Issued Date
2021-12-01
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ISSN
20411723
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2-s2.0-85106914962
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Communications. Vol.12, No.1 (2021)
Suggested Citation
Ernest Diez Benavente, Emilia Manko, Jody Phelan, Monica Campos, Debbie Nolder, Diana Fernandez, Gabriel Velez-Tobon, Alberto Tobón Castaño, Jamille G. Dombrowski, Claudio R.F. Marinho, Anna Caroline C. Aguiar, Dhelio Batista Pereira, Kanlaya Sriprawat, Francois Nosten, Robert Moon, Colin J. Sutherland, Susana Campino, Taane G. Clark Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa. Nature Communications. Vol.12, No.1 (2021). doi:10.1038/s41467-021-23422-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75933
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Title
Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa
Author(s)
Ernest Diez Benavente
Emilia Manko
Jody Phelan
Monica Campos
Debbie Nolder
Diana Fernandez
Gabriel Velez-Tobon
Alberto Tobón Castaño
Jamille G. Dombrowski
Claudio R.F. Marinho
Anna Caroline C. Aguiar
Dhelio Batista Pereira
Kanlaya Sriprawat
Francois Nosten
Robert Moon
Colin J. Sutherland
Susana Campino
Taane G. Clark
Emilia Manko
Jody Phelan
Monica Campos
Debbie Nolder
Diana Fernandez
Gabriel Velez-Tobon
Alberto Tobón Castaño
Jamille G. Dombrowski
Claudio R.F. Marinho
Anna Caroline C. Aguiar
Dhelio Batista Pereira
Kanlaya Sriprawat
Francois Nosten
Robert Moon
Colin J. Sutherland
Susana Campino
Taane G. Clark
Abstract
Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites. Signals of positive selection are linked to drug resistance-associated loci including pvkelch10, pvmrp1, pvdhfr and pvdhps, and two loci linked to P. vivax invasion of reticulocytes, pvrbp1a and pvrbp1b. Significant identity-by-descent was found in extended chromosome regions common to P. vivax from India and Ethiopia, including the pvdbp gene associated with Duffy blood group binding. Our investigation provides new understanding of global P. vivax population structure and genomic diversity, and genetic evidence of recent directional selection in this important human pathogen.