Publication: Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
Issued Date
2021-12-01
Resource Type
ISSN
2054345X
Other identifier(s)
2-s2.0-85100592571
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Human Genome Variation. Vol.8, No.1 (2021)
Suggested Citation
Chakkaphan Runcharoen, Koya Fukunaga, Insee Sensorn, Nareenart Iemwimangsa, Sommon Klumsathian, Hang Tong, Nam Sy Vo, Ly Le, Tin Maung Hlaing, Myo Thant, Shamsul Mohd Zain, Zahurin Mohamed, Yuh Fen Pung, Francis Capule, Jose Nevado, Catherine Lynn Silao, Zeina N. Al-Mahayri, Bassam R. Ali, Rika Yuliwulandari, Kinasih Prayuni, Hilyatuz Zahroh, Dzul Azri Mohamed Noor, Phonepadith Xangsayarath, Dalouny Xayavong, Sengchanh Kounnavong, Somphou Sayasone, Zoe Kordou, Ioannis Liopetas, Athina Tsikrika, Evangelia Eirini Tsermpini, Maria Koromina, Christina Mitropoulou, George P. Patrinos, Aumpika Kesornsit, Angkana Charoenyingwattana, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol, Taisei Mushiroda, Wasun Chantratita Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Human Genome Variation. Vol.8, No.1 (2021). doi:10.1038/s41439-021-00135-z Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75952
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Title
Prevalence of pharmacogenomic variants in 100 pharmacogenes among Southeast Asian populations under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm)
Author(s)
Chakkaphan Runcharoen
Koya Fukunaga
Insee Sensorn
Nareenart Iemwimangsa
Sommon Klumsathian
Hang Tong
Nam Sy Vo
Ly Le
Tin Maung Hlaing
Myo Thant
Shamsul Mohd Zain
Zahurin Mohamed
Yuh Fen Pung
Francis Capule
Jose Nevado
Catherine Lynn Silao
Zeina N. Al-Mahayri
Bassam R. Ali
Rika Yuliwulandari
Kinasih Prayuni
Hilyatuz Zahroh
Dzul Azri Mohamed Noor
Phonepadith Xangsayarath
Dalouny Xayavong
Sengchanh Kounnavong
Somphou Sayasone
Zoe Kordou
Ioannis Liopetas
Athina Tsikrika
Evangelia Eirini Tsermpini
Maria Koromina
Christina Mitropoulou
George P. Patrinos
Aumpika Kesornsit
Angkana Charoenyingwattana
Sukanya Wattanapokayakit
Surakameth Mahasirimongkol
Taisei Mushiroda
Wasun Chantratita
Koya Fukunaga
Insee Sensorn
Nareenart Iemwimangsa
Sommon Klumsathian
Hang Tong
Nam Sy Vo
Ly Le
Tin Maung Hlaing
Myo Thant
Shamsul Mohd Zain
Zahurin Mohamed
Yuh Fen Pung
Francis Capule
Jose Nevado
Catherine Lynn Silao
Zeina N. Al-Mahayri
Bassam R. Ali
Rika Yuliwulandari
Kinasih Prayuni
Hilyatuz Zahroh
Dzul Azri Mohamed Noor
Phonepadith Xangsayarath
Dalouny Xayavong
Sengchanh Kounnavong
Somphou Sayasone
Zoe Kordou
Ioannis Liopetas
Athina Tsikrika
Evangelia Eirini Tsermpini
Maria Koromina
Christina Mitropoulou
George P. Patrinos
Aumpika Kesornsit
Angkana Charoenyingwattana
Sukanya Wattanapokayakit
Surakameth Mahasirimongkol
Taisei Mushiroda
Wasun Chantratita
Other Contributor(s)
Faculty of Medicine, YARSI University
YARSI University
School of Pharmaceutical Sciences, Universiti Sains Malaysia
International University,Vietnam National University Ho Chi Minh City
The University of Nottingham Malaysia Campus
University of the Philippines Manila
University of the Philippines College of Medicine
College of Medicine and Health Sciences United Arab Emirates University
School of Health Sciences
Universiti Malaya
Riken
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Thailand Ministry of Public Health
Mahidol University
Defence Services Medical Research Centre
Defence Services Medical Academy
Vingroup Big Data Institute
Lao Tropical and Public Health Institute
The Golden Helix Foundation
National Center for Laboratory and Epidemiology
YARSI University
School of Pharmaceutical Sciences, Universiti Sains Malaysia
International University,Vietnam National University Ho Chi Minh City
The University of Nottingham Malaysia Campus
University of the Philippines Manila
University of the Philippines College of Medicine
College of Medicine and Health Sciences United Arab Emirates University
School of Health Sciences
Universiti Malaya
Riken
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Thailand Ministry of Public Health
Mahidol University
Defence Services Medical Research Centre
Defence Services Medical Academy
Vingroup Big Data Institute
Lao Tropical and Public Health Institute
The Golden Helix Foundation
National Center for Laboratory and Epidemiology
Abstract
Pharmacogenomics can enhance the outcome of treatment by adopting pharmacogenomic testing to maximize drug efficacy and lower the risk of serious adverse events. Next-generation sequencing (NGS) is a cost-effective technology for genotyping several pharmacogenomic loci at once, thereby increasing publicly available data. A panel of 100 pharmacogenes among Southeast Asian (SEA) populations was resequenced using the NGS platform under the collaboration of the Southeast Asian Pharmacogenomics Research Network (SEAPharm). Here, we present the frequencies of pharmacogenomic variants and the comparison of these pharmacogenomic variants among different SEA populations and other populations used as controls. We investigated the different types of pharmacogenomic variants, especially those that may have a functional impact. Our results provide substantial genetic variations at 100 pharmacogenomic loci among SEA populations that may contribute to interpopulation variability in drug response phenotypes. Correspondingly, this study provides basic information for further pharmacogenomic investigations in SEA populations.