Publication: Viral speciation through subcellular genetic isolation and virogenesis incompatibility
Issued Date
2021-12-01
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ISSN
20411723
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2-s2.0-85099353580
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Mahidol University
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SCOPUS
Bibliographic Citation
Nature Communications. Vol.12, No.1 (2021)
Suggested Citation
Vorrapon Chaikeeratisak, Erica A. Birkholz, Amy M. Prichard, MacKennon K.E. Egan, Avani Mylvara, Poochit Nonejuie, Katrina T. Nguyen, Joseph Sugie, Justin R. Meyer, Joe Pogliano Viral speciation through subcellular genetic isolation and virogenesis incompatibility. Nature Communications. Vol.12, No.1 (2021). doi:10.1038/s41467-020-20575-5 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/75954
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Title
Viral speciation through subcellular genetic isolation and virogenesis incompatibility
Abstract
Understanding how biological species arise is critical for understanding the evolution of life on Earth. Bioinformatic analyses have recently revealed that viruses, like multicellular life, form reproductively isolated biological species. Viruses are known to share high rates of genetic exchange, so how do they evolve genetic isolation? Here, we evaluate two related bacteriophages and describe three factors that limit genetic exchange between them: 1) A nucleus-like compartment that physically separates replicating phage genomes, thereby limiting inter-phage recombination during co-infection; 2) A tubulin-based spindle that orchestrates phage replication and forms nonfunctional hybrid polymers; and 3) A nuclear incompatibility factor that reduces phage fitness. Together, these traits maintain species differences through Subcellular Genetic Isolation where viral genomes are physically separated during co-infection, and Virogenesis Incompatibility in which the interaction of cross-species components interferes with viral production.