Publication: A Rhodamine‐based Fluorescent Chemodosimeter for Au<sup>3+</sup> in Aqueous Solution and Living Cells
Issued Date
2021-07-01
Resource Type
ISSN
15734994
10530509
10530509
Other identifier(s)
2-s2.0-85106730234
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Fluorescence. Vol.31, No.4 (2021), 1211-1218
Suggested Citation
Chariwat Pitsanuwong, Juthamanee Boonwan, Sinchai Chomngam, Kanokorn Wechakorn, Phongthon Kanjanasirirat, Yongyut Pewkliang, Suparerk Borwornpinyo, Palangpon Kongsaeree A Rhodamine‐based Fluorescent Chemodosimeter for Au<sup>3+</sup> in Aqueous Solution and Living Cells. Journal of Fluorescence. Vol.31, No.4 (2021), 1211-1218. doi:10.1007/s10895-021-02725-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76126
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Title
A Rhodamine‐based Fluorescent Chemodosimeter for Au<sup>3+</sup> in Aqueous Solution and Living Cells
Abstract
A highly selective rhodamine hydrazide-based fluorescent chemosensor for Au3+ detection was developed. The aqueous solution of rhodamine N-hydroxysemicarbazide (RHS), in the presence of Au3+, exhibited a significant 55-fold turn-on fluorescence response at 591 nm and a colorimetric change from colorless to pink. Other interested ions including Li+, Na+, K+, Cs+, Mg2+, Ca2+, Ba2+, Pb2+, Mn2+, Co2+, Ni2+, Ag+, Cd2+, Cu2+, Hg2+, Zn2+, Sn2+, Fe2+, Fe3+, Cr3+, Ce3+ did not induce any distinct color/spectral changes. The irreversible detection mechanism occurred via Au3+-promoted 5-exo-trig ring closure to yield 1,3,4-oxadiazole-2-one product. The RHS probe is non-responsive to other biologically relevant metal ions and the limit of detection for Au3+ was calculated to be 0.5 µM with a linear range of 0 to 90 µM. Fluorescence bioimaging of Au3+ in HepG2 cells was also successfully demonstrated.