Publication: The epidemiology, diagnosis and management of scrub typhus disease in China
Issued Date
2021-01-01
Resource Type
ISSN
2164554X
21645515
21645515
Other identifier(s)
2-s2.0-85107894302
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Mahidol University
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SCOPUS
Bibliographic Citation
Human Vaccines and Immunotherapeutics. Vol.17, No.10 (2021), 3795-3805
Suggested Citation
Taha Hussein Musa, Tauseef Ahmad, Mohammed Nasiru Wana, Wei Li, Hassan Hussein Musa, Khan Sharun, Ruchi Tiwari, Kuldeep Dhama, Wanpen Chaicumpa, Michael C. Campbell, Pingmin Wei The epidemiology, diagnosis and management of scrub typhus disease in China. Human Vaccines and Immunotherapeutics. Vol.17, No.10 (2021), 3795-3805. doi:10.1080/21645515.2021.1934355 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77350
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Title
The epidemiology, diagnosis and management of scrub typhus disease in China
Abstract
Thirty-nine years ago, scrub typhus (ST), a disease, was not among the China’s notifiable diseases. However, ST has reemerged to become a growing public health issue in the southwest part of China. The major factors contributing to an increased incidence and prevalence of this disease include rapid globalization, urbanization, expansion of humans into previously uninhabited areas, and climate change. The clinical manifestation of ST also consists of high fever, headache, weakness, myalgia, rash, and an eschar. In severe cases, complications (e.g. multi-organ failure, jaundice, acute renal failure, pneumonitis, myocarditis, and even death) can occur. The diagnosis of ST is mainly based on serological identification by indirect immunofluorescence assay and other molecular methods. Furthermore, several groups of antibiotics (e.g. tetracycline, chloramphenicol, macrolides, and rifampicin) are currently effective in treating this disease. This fact suggests the need for robust early diagnostic techniques, increased surveillance, and prompt treatment, and develop future vaccine.