Publication: Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
Issued Date
2021-12-01
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ISSN
1466609X
13648535
13648535
Other identifier(s)
2-s2.0-85106149798
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Critical Care. Vol.25, No.1 (2021)
Suggested Citation
Luis Morales-Quinteros, Ary Serpa Neto, Antonio Artigas, Lluis Blanch, Michela Botta, David A. Kaufman, Marcus J. Schultz, Anissa M. Tsonas, Frederique Paulus, Lieuwe D. Bos, A. G. Algera, L. S. Boers, J. Pillay, D. A. Dongelmans, M. W. Hollmann, J. Horn, A. P. Vlaar, J. P. van Akkeren, A. G. Algera, C. K. Algoe, R. B. van Amstel, O. L. Baur, P. van de Berg, A. E. van den Berg, D. C.J.J. Bergmans, D. I. van den Bersselaar, F. A. Bertens, A. J.G.H. Bindels, M. M. de Boer, S. den Boer, M. Bogerd, J. S. Breel, H. de Bruin, S. de Bruin, C. L. Bruna, L. A. Buiteman–Kruizinga, O. Cremer, R. M. Determann, W. Dieperink, H. S. Franke, M. S. Galek–Aldridge, M. J. de Graaff, L. A. Hagens, J. J. Haringman, S. T. van der Heide, P. L.J. van der Heiden, N. F.L. Heijnen, S. J.P. Hiel, L. L. Hoeijmakers, L. Hol, M. W. Hollmann, M. E. Hoogendoorn, R. van der Horst, E. L.K. Ie, D. Ivanov, N. P. Juffermans, E. Kho, E. S. de Klerk, A. W.M.M.Koopman van Gemert, M. Koopmans, S. Kucukcelebi, M. A. Kuiper, D. W. de Lange, N. van Mourik, S. G. Nijbroek, M. Onrust, E. A.N. Oostdijk, C. J. Pennartz, L. Pisani, I. M. Purmer, T. C.D. Rettig, J. P. Roozeman, M. T.U. Schuijt, M. E. Sleeswijk, M. R. Smit, P. E. Spronk, W. Stilma, A. C. Strang, P. R. Tuinman, C. M.A. Valk, F. L. Veen-Schra, L. I. Veldhuis, P. van Velzen, W. H. van der Ven, P. van Vliet, P. H.J. van der Voort, L. van Welie, H. J.F.T. Wesselink, H. H. van der Wier-Lubbers, B. van Wijk, T. Winters, W. Y. Wong, A. R.H. van Zanten Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS. Critical Care. Vol.25, No.1 (2021). doi:10.1186/s13054-021-03570-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/77584
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Title
Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS
Author(s)
Luis Morales-Quinteros
Ary Serpa Neto
Antonio Artigas
Lluis Blanch
Michela Botta
David A. Kaufman
Marcus J. Schultz
Anissa M. Tsonas
Frederique Paulus
Lieuwe D. Bos
A. G. Algera
L. S. Boers
J. Pillay
D. A. Dongelmans
M. W. Hollmann
J. Horn
A. P. Vlaar
J. P. van Akkeren
A. G. Algera
C. K. Algoe
R. B. van Amstel
O. L. Baur
P. van de Berg
A. E. van den Berg
D. C.J.J. Bergmans
D. I. van den Bersselaar
F. A. Bertens
A. J.G.H. Bindels
M. M. de Boer
S. den Boer
M. Bogerd
J. S. Breel
H. de Bruin
S. de Bruin
C. L. Bruna
L. A. Buiteman–Kruizinga
O. Cremer
R. M. Determann
W. Dieperink
H. S. Franke
M. S. Galek–Aldridge
M. J. de Graaff
L. A. Hagens
J. J. Haringman
S. T. van der Heide
P. L.J. van der Heiden
N. F.L. Heijnen
S. J.P. Hiel
L. L. Hoeijmakers
L. Hol
M. W. Hollmann
M. E. Hoogendoorn
R. van der Horst
E. L.K. Ie
D. Ivanov
N. P. Juffermans
E. Kho
E. S. de Klerk
A. W.M.M.Koopman van Gemert
M. Koopmans
S. Kucukcelebi
M. A. Kuiper
D. W. de Lange
N. van Mourik
S. G. Nijbroek
M. Onrust
E. A.N. Oostdijk
C. J. Pennartz
L. Pisani
I. M. Purmer
T. C.D. Rettig
J. P. Roozeman
M. T.U. Schuijt
M. E. Sleeswijk
M. R. Smit
P. E. Spronk
W. Stilma
A. C. Strang
P. R. Tuinman
C. M.A. Valk
F. L. Veen-Schra
L. I. Veldhuis
P. van Velzen
W. H. van der Ven
P. van Vliet
P. H.J. van der Voort
L. van Welie
H. J.F.T. Wesselink
H. H. van der Wier-Lubbers
B. van Wijk
T. Winters
W. Y. Wong
A. R.H. van Zanten
Ary Serpa Neto
Antonio Artigas
Lluis Blanch
Michela Botta
David A. Kaufman
Marcus J. Schultz
Anissa M. Tsonas
Frederique Paulus
Lieuwe D. Bos
A. G. Algera
L. S. Boers
J. Pillay
D. A. Dongelmans
M. W. Hollmann
J. Horn
A. P. Vlaar
J. P. van Akkeren
A. G. Algera
C. K. Algoe
R. B. van Amstel
O. L. Baur
P. van de Berg
A. E. van den Berg
D. C.J.J. Bergmans
D. I. van den Bersselaar
F. A. Bertens
A. J.G.H. Bindels
M. M. de Boer
S. den Boer
M. Bogerd
J. S. Breel
H. de Bruin
S. de Bruin
C. L. Bruna
L. A. Buiteman–Kruizinga
O. Cremer
R. M. Determann
W. Dieperink
H. S. Franke
M. S. Galek–Aldridge
M. J. de Graaff
L. A. Hagens
J. J. Haringman
S. T. van der Heide
P. L.J. van der Heiden
N. F.L. Heijnen
S. J.P. Hiel
L. L. Hoeijmakers
L. Hol
M. W. Hollmann
M. E. Hoogendoorn
R. van der Horst
E. L.K. Ie
D. Ivanov
N. P. Juffermans
E. Kho
E. S. de Klerk
A. W.M.M.Koopman van Gemert
M. Koopmans
S. Kucukcelebi
M. A. Kuiper
D. W. de Lange
N. van Mourik
S. G. Nijbroek
M. Onrust
E. A.N. Oostdijk
C. J. Pennartz
L. Pisani
I. M. Purmer
T. C.D. Rettig
J. P. Roozeman
M. T.U. Schuijt
M. E. Sleeswijk
M. R. Smit
P. E. Spronk
W. Stilma
A. C. Strang
P. R. Tuinman
C. M.A. Valk
F. L. Veen-Schra
L. I. Veldhuis
P. van Velzen
W. H. van der Ven
P. van Vliet
P. H.J. van der Voort
L. van Welie
H. J.F.T. Wesselink
H. H. van der Wier-Lubbers
B. van Wijk
T. Winters
W. Y. Wong
A. R.H. van Zanten
Other Contributor(s)
Institut d’Investigació i Innovació Parc Taulí (I3PT)
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
University of Melbourne
NYU Grossman School of Medicine
Universitat Autònoma de Barcelona
Monash University
Hospital Israelita Albert Einstein
Mahidol University
Hospital Universitari de Bellvitge
Nuffield Department of Medicine
Amsterdam UMC - University of Amsterdam
UDIAT, Corporación Sanitaria Universitaria Parc Taulí
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
University of Melbourne
NYU Grossman School of Medicine
Universitat Autònoma de Barcelona
Monash University
Hospital Israelita Albert Einstein
Mahidol University
Hospital Universitari de Bellvitge
Nuffield Department of Medicine
Amsterdam UMC - University of Amsterdam
UDIAT, Corporación Sanitaria Universitaria Parc Taulí
Abstract
Background: Estimates for dead space ventilation have been shown to be independently associated with an increased risk of mortality in the acute respiratory distress syndrome and small case series of COVID-19-related ARDS. Methods: Secondary analysis from the PRoVENT-COVID study. The PRoVENT-COVID is a national, multicenter, retrospective observational study done at 22 intensive care units in the Netherlands. Consecutive patients aged at least 18 years were eligible for participation if they had received invasive ventilation for COVID-19 at a participating ICU during the first month of the national outbreak in the Netherlands. The aim was to quantify the dynamics and determine the prognostic value of surrogate markers of wasted ventilation in patients with COVID-19-related ARDS. Results: A total of 927 consecutive patients admitted with COVID-19-related ARDS were included in this study. Estimations of wasted ventilation such as the estimated dead space fraction (by Harris–Benedict and direct method) and ventilatory ratio were significantly higher in non-survivors than survivors at baseline and during the following days of mechanical ventilation (p < 0.001). The end-tidal-to-arterial PCO2 ratio was lower in non-survivors than in survivors (p < 0.001). As ARDS severity increased, mortality increased with successive tertiles of dead space fraction by Harris–Benedict and by direct estimation, and with an increase in the VR. The same trend was observed with decreased levels in the tertiles for the end-tidal-to-arterial PCO2 ratio. After adjustment for a base risk model that included chronic comorbidities and ventilation- and oxygenation-parameters, none of the dead space estimates measured at the start of ventilation or the following days were significantly associated with 28-day mortality. Conclusions: There is significant impairment of ventilation in the early course of COVID-19-related ARDS but quantification of this impairment does not add prognostic information when added to a baseline risk model. Trial registration: ISRCTN04346342. Registered 15 April 2020. Retrospectively registered.