Publication: Safety concerns with glass particle contamination: Improving the standard guidelines for preparing medication injections
Issued Date
2021-06-01
Resource Type
ISSN
14643677
13534505
13534505
Other identifier(s)
2-s2.0-85109354644
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal for Quality in Health Care. Vol.33, No.2 (2021)
Suggested Citation
Natthacha Chiannilkulchai, Siranee Kejkornkaew Safety concerns with glass particle contamination: Improving the standard guidelines for preparing medication injections. International Journal for Quality in Health Care. Vol.33, No.2 (2021). doi:10.1093/intqhc/mzab091 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78135
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Title
Safety concerns with glass particle contamination: Improving the standard guidelines for preparing medication injections
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Abstract
Background: Glass ampoules are widely used to contain injection medications because of their properties. However, the existing literature reports that glass particle contamination is found in opening glass ampoules. To date, nursing practice standards on this issue have not gained attention in terms of the manual breaking methods generally used for opening ampoules in a clinical setting that can minimize the risk of glass particle contamination and, therefore, increase patient safety. Objective: This study aimed to compare manual breaking methods commonly used to open ampoules in clinical practice that affected the number of glass particles and to identify the factors influencing glass particle contamination. Methods: We used a comparative research design to evaluate the manual breaking methods for opening medication ampoules among 56 registered nurses from diverse clinical areas in a university hospital. Each participant broke 12 ampoules in two sizes using six methods, each method combined with wrapping material and one breaking direction. We measured the number of glass particles in five sizes for each method and the factors influencing glass particle contamination. Results: In total, 449 of 672 ampoules were contaminated with glass particles. Breaking the ampoule with a cotton ball (partial ampoule neck wrapping) from an outward direction resulted in the fewest glass particles, while breaking the ampoule with a gauze pad (entire ampoule neck wrapping) from an inward direction resulted in the most glass particles. Breaking method, ampoule size and clinical experience significantly influence glass particle contamination (P < 0.05). Conclusions: The method (wrapping technique and breaking direction) that nurses use to break ampoules affects the number of glass particles. Therefore, improving the standard guidelines for preparing medication injections and training in breaking methods for opening ampoules is essential.