Publication: Serological evidence indicates widespread distribution of rickettsioses in Myanmar
Issued Date
2021-02-01
Resource Type
ISSN
18783511
12019712
12019712
Other identifier(s)
2-s2.0-85099000315
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Mahidol University
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SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases. Vol.103, (2021), 494-501
Suggested Citation
Philip N.D. Elders, Myo Maung Maung Swe, Aung Pyae Phyo, Alistair R.D. McLean, Htet Naing Lin, Kyaw Soe, Wei Yan Aung Htay, Ampai Tanganuchitcharnchai, Thel K. Hla, Ni Ni Tun, Thin Thin Nwe, Myat Myat Moe, Win May Thein, Ni Ni Zaw, Wai Mon Kyaw, Htun Linn, Yin Yin Htwe, Frank M. Smithuis, Stuart D. Blacksell, Elizabeth A. Ashley Serological evidence indicates widespread distribution of rickettsioses in Myanmar. International Journal of Infectious Diseases. Vol.103, (2021), 494-501. doi:10.1016/j.ijid.2020.12.013 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/78485
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Title
Serological evidence indicates widespread distribution of rickettsioses in Myanmar
Author(s)
Philip N.D. Elders
Myo Maung Maung Swe
Aung Pyae Phyo
Alistair R.D. McLean
Htet Naing Lin
Kyaw Soe
Wei Yan Aung Htay
Ampai Tanganuchitcharnchai
Thel K. Hla
Ni Ni Tun
Thin Thin Nwe
Myat Myat Moe
Win May Thein
Ni Ni Zaw
Wai Mon Kyaw
Htun Linn
Yin Yin Htwe
Frank M. Smithuis
Stuart D. Blacksell
Elizabeth A. Ashley
Myo Maung Maung Swe
Aung Pyae Phyo
Alistair R.D. McLean
Htet Naing Lin
Kyaw Soe
Wei Yan Aung Htay
Ampai Tanganuchitcharnchai
Thel K. Hla
Ni Ni Tun
Thin Thin Nwe
Myat Myat Moe
Win May Thein
Ni Ni Zaw
Wai Mon Kyaw
Htun Linn
Yin Yin Htwe
Frank M. Smithuis
Stuart D. Blacksell
Elizabeth A. Ashley
Other Contributor(s)
Mahosot Hospital, Lao
Mahidol University
Nuffield Department of Medicine
Mandalay General Hospital and University of Medicine
Monywa University
Magway General Hospital and University of Medicine
Myanmar Oxford Clinical Research Unit
National Health Laboratory
Medical Action Myanmar
University of Medicine 2
Mahidol University
Nuffield Department of Medicine
Mandalay General Hospital and University of Medicine
Monywa University
Magway General Hospital and University of Medicine
Myanmar Oxford Clinical Research Unit
National Health Laboratory
Medical Action Myanmar
University of Medicine 2
Abstract
Background: Little research has been published on the prevalence of rickettsial infections in Myanmar. This study determined the seroprevalence of immunoglobulin G (IgG) antibodies to rickettsial species in different regions of Myanmar. Methods: Seven hundred leftover blood samples from patients of all ages in primary care clinics and hospitals in seven regions of Myanmar were collected. Samples were screened for scrub typhus group (STG), typhus group (TG) and spotted fever group (SFG) IgG antibodies using enzyme-linked immunosorbent assays (ELISA). Immunofluorescence assays were performed for the same rickettsial groups to confirm seropositivity if ELISA optical density ≥0.5. Results: Overall IgG seroprevalence was 19% [95% confidence interval (CI) 16–22%] for STG, 5% (95% CI 3–7%) for TG and 3% (95% CI: 2–5%) for SFG. The seroprevalence of STG was particularly high in northern and central Myanmar (59% and 19–33%, respectively). Increasing age was associated with higher odds of STG and TG seropositivity [per 10-year increase, adjusted odds ratio estimate 1.68 (p < 0.01) and 1.24 (p = 0.03), respectively]. Conclusion: Rickettsial infections are widespread in Myanmar, with particularly high seroprevalence of STG IgG antibodies in central and northern regions. Healthcare workers should consider rickettsial infections as common causes of fever in Myanmar.