Publication: To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?
Issued Date
2021-08-01
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ISSN
19326203
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2-s2.0-85114320947
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Mahidol University
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SCOPUS
Bibliographic Citation
PLoS ONE. Vol.16, No.8 August (2021)
Suggested Citation
Freek De Haan, Oladimeji Akeem Bolarinwa, Rosemonde Guissou, Fatoumata Tou, Paulina Tindana, Wouter P.C. Boon, Ellen H.M. Moors, Phaik Yeong Cheah, Mehul Dhorda, Arjen M. Dondorp, Jean Bosco Ouedraogo, Olugbenga A. Mokuolu, Chanaki Amaratunga To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?. PLoS ONE. Vol.16, No.8 August (2021). doi:10.1371/journal.pone.0256567 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/79320
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Title
To what extent are the antimalarial markets in African countries ready for a transition to triple artemisinin-based combination therapies?
Abstract
Introduction Triple artemisinin-based combination therapies (TACTs) are being developed as a response to artemisinin and partner drug resistance in the treatment of falciparum malaria in Southeast Asia. In African countries, where current artemisinin-based combination therapies (ACTs) are still effective, TACTs have the potential to benefit the larger community and future patients by mitigating the risk of drug resistance. This study explores the extent to which the antimalarial drug markets in African countries are ready for a transition to TACTs. Methods A qualitative study was conducted in Nigeria and Burkina Faso and comprised in-depth interviews (n = 68) and focus group discussions (n = 11) with key actor groups in the innovation system of antimalarial therapies. Results Evidence of ACT failure in African countries and explicit support for TACTs by the World Health Organization (WHO) and international funders were perceived important determinants for the market prospects of TACTs in Nigeria and Burkina Faso. At the country level, slow regulatory and implementation procedures were identified as potential barriers towards rapid TACTs deployment. Integrating TACTs in public sector distribution channels was considered relatively straightforward. More challenges were expected for integrating TACTs in private sector distribution channels, which are characterized by patient demand and profit motives. Finally, several affordability and acceptability issues were raised for which ACTs were suggested as a benchmark. Conclusion The market prospects of TACTs in Nigeria and Burkina Faso will depend on the demonstration of the added value of TACTs over ACTs, their advocacy by the WHO, the inclusion of TACTs in financial and regulatory arrangements, and their alignment with current distribution and deployment practices. Further clinical, health-economic and feasibility studies are required to inform decision makers about the broader implications of a transition to TACTs in African counties. The recent reporting of artemisinin resistance and ACT failure in Africa might change important determinants of the market readiness for TACTs.