Miniaturizing chemistry and biology using droplets in open systems
Issued Date
2023-01-01
Resource Type
eISSN
23973358
Scopus ID
2-s2.0-85153037584
Journal Title
Nature Reviews Chemistry
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nature Reviews Chemistry (2023)
Suggested Citation
Zeng Y., Khor J.W., van Neel T.L., Tu W.c., Berthier J., Thongpang S., Berthier E., Theberge A.B. Miniaturizing chemistry and biology using droplets in open systems. Nature Reviews Chemistry (2023). doi:10.1038/s41570-023-00483-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81763
Title
Miniaturizing chemistry and biology using droplets in open systems
Author's Affiliation
Other Contributor(s)
Abstract
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They combine the compartmentalization and control offered by traditional droplet-based microfluidics with the accessibility and ease-of-use of open microfluidics, bringing unique advantages to applications such as combinatorial reactions, droplet analysis and cell culture. Open systems provide direct access to droplets and allow on-demand droplet manipulation within the system without needing pumps or tubes, which makes the systems accessible to biologists without sophisticated setups. Furthermore, these systems can be produced with simple manufacturing and assembly steps that allow for manufacturing at scale and the translation of the method into clinical research. This Review introduces the different types of open droplet microfluidic system, presents the physical concepts leveraged by these systems and highlights key applications. [Figure not available: see fulltext.]