Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects
Issued Date
2022-12-01
Resource Type
eISSN
2076393X
Scopus ID
2-s2.0-85144661069
Journal Title
Vaccines
Volume
10
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Vaccines Vol.10 No.12 (2022)
Suggested Citation
Gupta M., Wahi A., Sharma P., Nagpal R., Raina N., Kaurav M., Bhattacharya J., Rodrigues Oliveira S.M., Dolma K.G., Paul A.K., de Lourdes Pereira M., Wilairatana P., Rahmatullah M., Nissapatorn V. Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects. Vaccines Vol.10 No.12 (2022). doi:10.3390/vaccines10122011 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84834
Title
Recent Advances in Cancer Vaccines: Challenges, Achievements, and Futuristic Prospects
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Sikkim Manipal Institute of Medical Sciences
KIET Group of Institutions
Hunter Medical Research Institute, Australia
Jawaharlal Nehru University
Walailak University
Universidade de Aveiro
University of Tasmania
CICECO – Instituto de Materiais de Aveiro
University of Development Alternative
Delhi Pharmaceutical Sciences and Research University
Sikkim Manipal Institute of Medical Sciences
KIET Group of Institutions
Hunter Medical Research Institute, Australia
Jawaharlal Nehru University
Walailak University
Universidade de Aveiro
University of Tasmania
CICECO – Instituto de Materiais de Aveiro
University of Development Alternative
Delhi Pharmaceutical Sciences and Research University
Other Contributor(s)
Abstract
Cancer is a chronic disease, and it can be lethal due to limited therapeutic options. The conventional treatment options for cancer have numerous challenges, such as a low blood circulation time as well as poor solubility of anticancer drugs. Therapeutic cancer vaccines emerged to try to improve anticancer drugs’ efficiency and to deliver them to the target site. Cancer vaccines are considered a viable therapeutic technique for most solid tumors. Vaccines boost antitumor immunity by delivering tumor antigens, nucleic acids, entire cells, and peptides. Cancer vaccines are designed to induce long-term antitumor memory, causing tumor regression, eradicate minimal residual illness, and prevent non-specific or unpleasant effects. These vaccines can assist in the elimination of cancer cells from various organs or organ systems in the body, with minimal risk of tumor recurrence or metastasis. Vaccines and antigens for anticancer therapy are discussed in this review, including current vaccine adjuvants and mechanisms of action for various types of vaccines, such as DNA- or mRNA-based cancer vaccines. Potential applications of these vaccines focusing on their clinical use for better therapeutic efficacy are also discussed along with the latest research available in this field.