Human Virome in Cervix Controlled by the Domination of Human Papillomavirus
Issued Date
2022-09-01
Resource Type
eISSN
19994915
Scopus ID
2-s2.0-85138382030
Pubmed ID
36146871
Journal Title
Viruses
Volume
14
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Viruses Vol.14 No.9 (2022)
Suggested Citation
Sasivimolrattana T., Chantratita W., Sensorn I., Chaiwongkot A., Oranratanaphan S., Bhattarakosol P. Human Virome in Cervix Controlled by the Domination of Human Papillomavirus. Viruses Vol.14 No.9 (2022). doi:10.3390/v14092066 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84915
Title
Human Virome in Cervix Controlled by the Domination of Human Papillomavirus
Author's Affiliation
Other Contributor(s)
Abstract
Although other co-viral infections could also be considered influencing factors, cervical human papillomavirus (HPV) infection is the main cause of cervical cancer. Metagenomics have been employed in the NGS era to study the microbial community in each habitat. Thus, in this investigation, virome capture sequencing was used to examine the virome composition in the HPV-infected cervix. Based on the amount of HPV present in each sample, the results revealed that the cervical virome of HPV-infected individuals could be split into two categories: HPV-dominated (HD; ≥60%) and non-HPV-dominated (NHD; <60%). Cervical samples contained traces of several human viral species, including the molluscum contagiosum virus (MCV), human herpesvirus 4 (HHV4), torque teno virus (TTV), and influenza A virus. When compared to the HD group, the NHD group had a higher abundance of several viruses. Human viral diversity appears to be influenced by HPV dominance. This is the first proof that the diversity of human viruses in the cervix is impacted by HPV abundance. However, more research is required to determine whether human viral variety and the emergence of cancer are related.