Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
Issued Date
2022-03-01
Resource Type
eISSN
19994915
Scopus ID
2-s2.0-85125671828
Pubmed ID
35336883
Journal Title
Viruses
Volume
14
Issue
3
Rights Holder(s)
SCOPUS
Bibliographic Citation
Viruses Vol.14 No.3 (2022)
Suggested Citation
Sirinam S., Chatchen S., Arunsodsai W., Guharat S., Limkittikul K. Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic. Viruses Vol.14 No.3 (2022). doi:10.3390/v14030476 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85013
Title
Seroprevalence of Zika Virus in Amphawa District, Thailand, after the 2016 Pandemic
Author's Affiliation
Other Contributor(s)
Abstract
In 2016, Zika virus (ZIKV) infection was declared a public health emergency of international concern because of the neurological consequences in babies born to infected people. Because of the mild and nonspecific symptoms, serological tests are essential in epidemiological studies. However, cross-reactive antibodies between other Flaviviridae members may complicate the interpretation of results of these tests. This study investigated the seroprevalence of ZIKV infection in Samut Songkhram in central Thailand which was affected by the Zika outbreak of 2016. Three hundred and fifty volunteers aged 5–50 years in Amphawa District, Samut Songkhram, were enrolled between April 2017 and April 2018. ZIKV nonstructural protein 1 (NS1) immunoglobulin G enzyme-linked immunosorbent assay (ELISA) was used to screen serum samples collected on the first day of enrollment and after 6 and 12 months. The seroprevalence and seroconversion of ZIKV were assessed. Cases of ZIKV seroconversion were verified as evidence of ZIKV infection by NS1 blockade-of-binding ELISA and plaque reduction neutralization test (PRNT50). ZIKV seroprevalence in Amphawa was 15.1–17.8% with no significant change over the year. The total seroconversion rate throughout the year was 7/100 person-years. The ratio of asymptomatic to symptomatic infections was 4.5:1. The cases in our study confirmed the occurrence of occult ZIKV infections in the community. These undetected infections might promote the spread of ZIKV in vulnerable groups of the community.