Chitosan oligosaccharide mitigates kidney injury in prediabetic rats by improving intestinal barrier and renal autophagy
Issued Date
2022-07-15
Resource Type
ISSN
01448617
Scopus ID
2-s2.0-85126994277
Pubmed ID
35450657
Journal Title
Carbohydrate Polymers
Volume
288
Rights Holder(s)
SCOPUS
Bibliographic Citation
Carbohydrate Polymers Vol.288 (2022)
Suggested Citation
Sutthasupha P., Promsan S., Thongnak L., Pengrattanachot N., Phengpol N., Jaruan O., Jaikumkao K., Muanprasat C., Pichyangkura R., Chatsudthipong V., Lungkaphin A. Chitosan oligosaccharide mitigates kidney injury in prediabetic rats by improving intestinal barrier and renal autophagy. Carbohydrate Polymers Vol.288 (2022). doi:10.1016/j.carbpol.2022.119405 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85078
Title
Chitosan oligosaccharide mitigates kidney injury in prediabetic rats by improving intestinal barrier and renal autophagy
Other Contributor(s)
Abstract
Consumption of a high-fat diet (HFD) not only increases the risk of metabolic syndrome but also initiates kidney injury. Lipid accumulation-induced systemic low-grade inflammation is an upstream mechanism of kidney injury associated with prediabetes. Chitosan oligosaccharide (COS) provides potent anti-obesity effects through several mechanisms including fecal lipid excretion. In this study, we investigated the effects of COS on the prevention of obesity-related complications and its ability to confer renoprotection in a prediabetic model. Rats fed on a HFD developed obesity, glucose intolerance and kidney dysfunction. COS intervention successfully ameliorated these conditions (p < 0.05) by attenuating intestinal lipid absorption and the renal inflammation-autophagy-apoptosis axis. A novel anti-inflammatory effect of COS had been demonstrated by the strengthening of intestinal barrier integrity via calcium-sensing receptor (p < 0.05). The use of COS as a supplement may be useful in reducing prediabetic complications especially renal injury and the risk of type 2 diabetes.