BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region
Issued Date
2023-02-01
Resource Type
ISSN
14642662
eISSN
14681293
Scopus ID
2-s2.0-85133752819
Pubmed ID
35748404
Journal Title
HIV Medicine
Volume
24
Issue
2
Start Page
139
End Page
152
Rights Holder(s)
SCOPUS
Bibliographic Citation
HIV Medicine Vol.24 No.2 (2023) , 139-152
Suggested Citation
Khuon D., Rupasinghe D., Saphonn V., Kwong T.S., Widhani A., Chaiwarith R., Ly P.S., Do C.D., Avihingsanon A., Khusuwan S., Merati T.P., Van Nguyen K., Kumarasamy N., Chan Y.J., Azwa I., Ng O.T., Kiertiburanakul S., Tanuma J., Pujari S., Ditangco R., Zhang F., Choi J.Y., Gani Y., Sangle S., Ross J., Gorbach P.M., Jiamsakul A. BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region. HIV Medicine Vol.24 No.2 (2023) , 139-152. 152. doi:10.1111/hiv.13351 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85132
Title
BMI as a predictor of high fasting blood glucose among people living with HIV in the Asia-Pacific region
Author(s)
Khuon D.
Rupasinghe D.
Saphonn V.
Kwong T.S.
Widhani A.
Chaiwarith R.
Ly P.S.
Do C.D.
Avihingsanon A.
Khusuwan S.
Merati T.P.
Van Nguyen K.
Kumarasamy N.
Chan Y.J.
Azwa I.
Ng O.T.
Kiertiburanakul S.
Tanuma J.
Pujari S.
Ditangco R.
Zhang F.
Choi J.Y.
Gani Y.
Sangle S.
Ross J.
Gorbach P.M.
Jiamsakul A.
Rupasinghe D.
Saphonn V.
Kwong T.S.
Widhani A.
Chaiwarith R.
Ly P.S.
Do C.D.
Avihingsanon A.
Khusuwan S.
Merati T.P.
Van Nguyen K.
Kumarasamy N.
Chan Y.J.
Azwa I.
Ng O.T.
Kiertiburanakul S.
Tanuma J.
Pujari S.
Ditangco R.
Zhang F.
Choi J.Y.
Gani Y.
Sangle S.
Ross J.
Gorbach P.M.
Jiamsakul A.
Author's Affiliation
Hospital Sungai Buloh
Beijing Ditan Hospital Capital Medical University
VHS Medical Centre India
Gokila
Bach Mai Hospital
Universitas Udayana
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
University of California, Los Angeles
The Kirby Institute
National Center for Global Health and Medicine
Yonsei University College of Medicine
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Queen Elizabeth Hospital Hong Kong
University of Malaya Medical Centre
Veterans General Hospital-Taipei
Faculty of Medicine, Chulalongkorn University
Tan Tock Seng Hospital
Chiang Mai University
BJ Government Medical College and Sassoon General Hospital
University of Health Sciences
National Hospital for Tropical Diseases
amfAR - The Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
National Center for HIV/AIDS
Beijing Ditan Hospital Capital Medical University
VHS Medical Centre India
Gokila
Bach Mai Hospital
Universitas Udayana
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
University of California, Los Angeles
The Kirby Institute
National Center for Global Health and Medicine
Yonsei University College of Medicine
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Queen Elizabeth Hospital Hong Kong
University of Malaya Medical Centre
Veterans General Hospital-Taipei
Faculty of Medicine, Chulalongkorn University
Tan Tock Seng Hospital
Chiang Mai University
BJ Government Medical College and Sassoon General Hospital
University of Health Sciences
National Hospital for Tropical Diseases
amfAR - The Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
National Center for HIV/AIDS
Other Contributor(s)
Abstract
Background: Non-Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia-Pacific region, using a World Health Organization BMI classification specific to Asian populations. Methods: This study included people living with HIV enrolled in a longitudinal cohort study from 2003 to 2019, receiving antiretroviral therapy (ART), and without prior tuberculosis. BMI at ART initiation was categorized using Asian BMI classifications: underweight (<18.5 kg/m2), normal (18.5–22.9 kg/m2), overweight (23–24.9 kg/m2), and obese (≥25 kg/m2). High FBG was defined as a single post-ART FBG measurement ≥126 mg/dL. Factors associated with high FBG were analyzed using Cox regression models stratified by site. Results: A total of 3939 people living with HIV (63% male) were included. In total, 50% had a BMI in the normal weight range, 23% were underweight, 13% were overweight, and 14% were obese. Median age at ART initiation was 34 years (interquartile range 29–41). Overall, 8% had a high FBG, with an incidence rate of 1.14 per 100 person-years. Factors associated with an increased hazard of high FBG included being obese (≥25 kg/m2) compared with normal weight (hazard ratio [HR] = 1.79; 95% confidence interval [CI] 1.31–2.44; p < 0.001) and older age compared with those aged ≤30 years (31–40 years: HR = 1.47; 95% CI 1.08–2.01; 41–50 years: HR = 2.03; 95% CI 1.42–2.90; ≥51 years: HR = 3.19; 95% CI 2.17–4.69; p < 0.001). Conclusion: People living with HIV with BMI >25 kg/m2 were at increased risk of high FBG. This indicates that regular assessments should be performed in those with high BMI, irrespective of the classification used.