Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality
Issued Date
2022-05-01
Resource Type
ISSN
22876391
eISSN
22876405
Scopus ID
2-s2.0-85134324558
Journal Title
Journal of Stroke
Volume
24
Issue
2
Start Page
256
End Page
265
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Stroke Vol.24 No.2 (2022) , 256-265
Suggested Citation
Nguyen T.N., Qureshi M.M., Klein P., Yamagami H., Abdalkader M., Mikulik R., Sathya A., Mansour O.Y., Czlonkowska A., Lo H., Field T.S., Charidimou A., Banerjee S., Yaghi S., Siegler J.E., Sedova P., Kwan J., de Sousa D.A., Demeestere J., Inoa V., Omran S.S., Zhang L., Michel P., Strambo D., Marto J.P., Nogueira R.G., Lereis V.P., Ma A., Enzinger C., Gattringer T., Rahman A., Bonnet T., De Raedt S., Lemmens R., Ligot N., Vandervorst F., Conforto A.B., Hidalgo R.C.T., Cuervo D.L.M., Neves L.d.O., da Silva I.L., Martins R.T., Rebello L.C., Santiago I.B., Alexiev F., Sakelarova T., Kalpachki R., Cora E.A., Kelly M.E., Pikula A., Chen H.S., Chen Y., Yang S., Bedekovic M.R., Čabal M., Tenora D., Dušek P., Fibrich P., Hrabanovska E., Hlaváčová H., Jurák L., Kadlckova J., Karpowicz I., Klečka L., Kovář M., Neumann J., Paloušková H., Reiser M., Rohan V., Skoda O., Škorňa M., Šimůnek L., Šrámek M., Drenck N., Sobh K., Strbian D., Lesaine E., Reiner P., Rouanet F., Sabben C., Boskamp S., Mbroh J., Nagel S., Poli S., Rosenkranz M., Thomalla G., Karapanayiotides T., Kargiotis O., Koutroulou I., Palaiodimou L., Tsivgoulis G., Guerra J.D.B., Huded V., Nagendra S., Prajapati C., Sylaja P.N., Sani A.F., Ghoreishi A., Hashemilar M., Sadeghi-Hokmabadi E. Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality. Journal of Stroke Vol.24 No.2 (2022) , 256-265. 265. doi:10.5853/jos.2022.00752 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85879
Title
Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality
Author(s)
Nguyen T.N.
Qureshi M.M.
Klein P.
Yamagami H.
Abdalkader M.
Mikulik R.
Sathya A.
Mansour O.Y.
Czlonkowska A.
Lo H.
Field T.S.
Charidimou A.
Banerjee S.
Yaghi S.
Siegler J.E.
Sedova P.
Kwan J.
de Sousa D.A.
Demeestere J.
Inoa V.
Omran S.S.
Zhang L.
Michel P.
Strambo D.
Marto J.P.
Nogueira R.G.
Lereis V.P.
Ma A.
Enzinger C.
Gattringer T.
Rahman A.
Bonnet T.
De Raedt S.
Lemmens R.
Ligot N.
Vandervorst F.
Conforto A.B.
Hidalgo R.C.T.
Cuervo D.L.M.
Neves L.d.O.
da Silva I.L.
Martins R.T.
Rebello L.C.
Santiago I.B.
Alexiev F.
Sakelarova T.
Kalpachki R.
Cora E.A.
Kelly M.E.
Pikula A.
Chen H.S.
Chen Y.
Yang S.
Bedekovic M.R.
Čabal M.
Tenora D.
Dušek P.
Fibrich P.
Hrabanovska E.
Hlaváčová H.
Jurák L.
Kadlckova J.
Karpowicz I.
Klečka L.
Kovář M.
Neumann J.
Paloušková H.
Reiser M.
Rohan V.
Skoda O.
Škorňa M.
Šimůnek L.
Šrámek M.
Drenck N.
Sobh K.
Strbian D.
Lesaine E.
Reiner P.
Rouanet F.
Sabben C.
Boskamp S.
Mbroh J.
Nagel S.
Poli S.
Rosenkranz M.
Thomalla G.
Karapanayiotides T.
Kargiotis O.
Koutroulou I.
Palaiodimou L.
Tsivgoulis G.
Guerra J.D.B.
Huded V.
Nagendra S.
Prajapati C.
Sylaja P.N.
Sani A.F.
Ghoreishi A.
Hashemilar M.
Sadeghi-Hokmabadi E.
Qureshi M.M.
Klein P.
Yamagami H.
Abdalkader M.
Mikulik R.
Sathya A.
Mansour O.Y.
Czlonkowska A.
Lo H.
Field T.S.
Charidimou A.
Banerjee S.
Yaghi S.
Siegler J.E.
Sedova P.
Kwan J.
de Sousa D.A.
Demeestere J.
Inoa V.
Omran S.S.
Zhang L.
Michel P.
Strambo D.
Marto J.P.
Nogueira R.G.
Lereis V.P.
Ma A.
Enzinger C.
Gattringer T.
Rahman A.
Bonnet T.
De Raedt S.
Lemmens R.
Ligot N.
Vandervorst F.
Conforto A.B.
Hidalgo R.C.T.
Cuervo D.L.M.
Neves L.d.O.
da Silva I.L.
Martins R.T.
Rebello L.C.
Santiago I.B.
Alexiev F.
Sakelarova T.
Kalpachki R.
Cora E.A.
Kelly M.E.
Pikula A.
Chen H.S.
Chen Y.
Yang S.
Bedekovic M.R.
Čabal M.
Tenora D.
Dušek P.
Fibrich P.
Hrabanovska E.
Hlaváčová H.
Jurák L.
Kadlckova J.
Karpowicz I.
Klečka L.
Kovář M.
Neumann J.
Paloušková H.
Reiser M.
Rohan V.
Skoda O.
Škorňa M.
Šimůnek L.
Šrámek M.
Drenck N.
Sobh K.
Strbian D.
Lesaine E.
Reiner P.
Rouanet F.
Sabben C.
Boskamp S.
Mbroh J.
Nagel S.
Poli S.
Rosenkranz M.
Thomalla G.
Karapanayiotides T.
Kargiotis O.
Koutroulou I.
Palaiodimou L.
Tsivgoulis G.
Guerra J.D.B.
Huded V.
Nagendra S.
Prajapati C.
Sylaja P.N.
Sani A.F.
Ghoreishi A.
Hashemilar M.
Sadeghi-Hokmabadi E.
Author's Affiliation
Mazumdar Shaw Medical Center
Vali-e-Asr Hospital, Zanjan University of Medical Sciences (ZUMS)
Klinički Bolnički Centar Sestre Milosrdnice
Neurosciences Research Center
Universidade de Lisboa
Hertie-Institut für klinische Hirnforschung
Krajská nemocnice Liberec, a.s.
Shenyang General Hospital of PLA
Institute of Psychiatry and Neurology, Warszawa
Universitair Ziekenhuis Brussel
Hospital Nossa Senhora da Conceicao
Universitas Airlangga
Hospital Moinhos de Vento
Fakultní Nemocnice u Sv. Anny v Brně
Hôpital Erasme
Hospital de Base do Distrito Federal
Hospital de Base
Všeobecná Fakultní Nemocnice v Praze
St George's University Hospitals NHS Foundation Trust
National Hospital Organization Osaka National Hospital
Grant Medical College
Albertinen in Besten Händen
Fondation Adolphe de Rothschild
KU Leuven– University Hospital Leuven
University of Colorado School of Medicine
Sree Chitra Tirunal Institute for Medical Sciences and Technology
University General Hospital of Thessaloniki "AHEPA"
Fundacion Para La Lucha Contra Las Enfermedades Neurologicas de La Infancia
Centre Hospitalier Universitaire Vaudois
Klinikum Ludwigshafen
Fakultni Nemocnice Brno
Centre Hospitalier Universitaire de Bordeaux
Hôpital Lariboisiere AP-HP
Faculty of Medicine
Santa Maria Hospital, Lisbon
Metropolitan Hospital, Athens
Royal University Hospital
Eberhard Karls Universität Tübingen
Helsinki University Hospital
University of Toronto
Charles University
Dalhousie University
Attikon University Hospital
Copenhagen University Hospital
Charing Cross Hospital
University of Pittsburgh Medical Center
University Hospital Alexandrovska
Brown University
Na Homolce Hospital
The University of British Columbia
Universidade de São Paulo
Royal North Shore Hospital
Medizinische Universität Graz
Universitätsklinikum Hamburg-Eppendorf
Fakultní Nemocnice Plzeň
Sir Salimullah Medical College
Boston Medical Center
Universitätsklinikum Heidelberg
Centro Hospitalar de Lisboa Ocidental Hospital de Egas Moniz
University of Tennessee Health Science Center
Blansko Hospital
Hospital General San Juan de Dios
Uherskohradišťská Hospital
El Hussein Alzahar University Hospital
Krajská zdravotní-Hospital Chomutov
Hospital Vyskov
Oblastní nemocnice Trutnov a. s.
Foshan Sanshui District People's Hospital
Military University Hospital
Hospital Pribram
Karvina Mining Hospital
Hospital Karlovy Vary
Hospital São Carlos
Hospital Jihlava
Cooper University
Faculty Hospital Ostrava
Hospital Ceske Budejovice
Vali-e-Asr Hospital, Zanjan University of Medical Sciences (ZUMS)
Klinički Bolnički Centar Sestre Milosrdnice
Neurosciences Research Center
Universidade de Lisboa
Hertie-Institut für klinische Hirnforschung
Krajská nemocnice Liberec, a.s.
Shenyang General Hospital of PLA
Institute of Psychiatry and Neurology, Warszawa
Universitair Ziekenhuis Brussel
Hospital Nossa Senhora da Conceicao
Universitas Airlangga
Hospital Moinhos de Vento
Fakultní Nemocnice u Sv. Anny v Brně
Hôpital Erasme
Hospital de Base do Distrito Federal
Hospital de Base
Všeobecná Fakultní Nemocnice v Praze
St George's University Hospitals NHS Foundation Trust
National Hospital Organization Osaka National Hospital
Grant Medical College
Albertinen in Besten Händen
Fondation Adolphe de Rothschild
KU Leuven– University Hospital Leuven
University of Colorado School of Medicine
Sree Chitra Tirunal Institute for Medical Sciences and Technology
University General Hospital of Thessaloniki "AHEPA"
Fundacion Para La Lucha Contra Las Enfermedades Neurologicas de La Infancia
Centre Hospitalier Universitaire Vaudois
Klinikum Ludwigshafen
Fakultni Nemocnice Brno
Centre Hospitalier Universitaire de Bordeaux
Hôpital Lariboisiere AP-HP
Faculty of Medicine
Santa Maria Hospital, Lisbon
Metropolitan Hospital, Athens
Royal University Hospital
Eberhard Karls Universität Tübingen
Helsinki University Hospital
University of Toronto
Charles University
Dalhousie University
Attikon University Hospital
Copenhagen University Hospital
Charing Cross Hospital
University of Pittsburgh Medical Center
University Hospital Alexandrovska
Brown University
Na Homolce Hospital
The University of British Columbia
Universidade de São Paulo
Royal North Shore Hospital
Medizinische Universität Graz
Universitätsklinikum Hamburg-Eppendorf
Fakultní Nemocnice Plzeň
Sir Salimullah Medical College
Boston Medical Center
Universitätsklinikum Heidelberg
Centro Hospitalar de Lisboa Ocidental Hospital de Egas Moniz
University of Tennessee Health Science Center
Blansko Hospital
Hospital General San Juan de Dios
Uherskohradišťská Hospital
El Hussein Alzahar University Hospital
Krajská zdravotní-Hospital Chomutov
Hospital Vyskov
Oblastní nemocnice Trutnov a. s.
Foshan Sanshui District People's Hospital
Military University Hospital
Hospital Pribram
Karvina Mining Hospital
Hospital Karlovy Vary
Hospital São Carlos
Hospital Jihlava
Cooper University
Faculty Hospital Ostrava
Hospital Ceske Budejovice
Other Contributor(s)
Abstract
Background and Purpose Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. Methods We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). Results There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. Conclusions During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT.