Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein
Issued Date
2023-12-01
Resource Type
eISSN
14764954
Scopus ID
2-s2.0-85162740813
Pubmed ID
37349086
Journal Title
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Volume
36
Issue
2
Rights Holder(s)
SCOPUS
Bibliographic Citation
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Vol.36 No.2 (2023) , 2222333
Suggested Citation
Bosco M., Romero R., Gallo D.M., Suksai M., Gotsch F., Jung E., Chaemsaithong P., Tarca A.L., Gomez-Lopez N., Arenas-Hernandez M., Meyyazhagan A., Al Qasem M., Franchi M.P., Grossman L.I., Aras S., Chaiworapongsa T. Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Vol.36 No.2 (2023) , 2222333. doi:10.1080/14767058.2023.2222333 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87787
Title
Clinical chorioamnionitis at term is characterized by changes in the plasma concentration of CHCHD2/MNRR1, a mitochondrial protein
Author's Affiliation
Inje University Paik Hospital
Universidad del Valle, Cali
Azienda Ospedaliera Universitaria Integrata Verona
Mutah University
University of Michigan Medical School
Michigan State University
Faculty of Medicine, Prince of Songkia University
Wayne State University School of Medicine
National Institute of Child Health and Human Development (NICHD)
Mahidol University
Wayne State University
Università degli Studi di Perugia
Universidad del Valle, Cali
Azienda Ospedaliera Universitaria Integrata Verona
Mutah University
University of Michigan Medical School
Michigan State University
Faculty of Medicine, Prince of Songkia University
Wayne State University School of Medicine
National Institute of Child Health and Human Development (NICHD)
Mahidol University
Wayne State University
Università degli Studi di Perugia
Other Contributor(s)
Abstract
OBJECTIVE: Mitochondrial dysfunction was observed in acute systemic inflammatory conditions such as sepsis and might be involved in sepsis-induced multi-organ failure. Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2), also known as Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1), a bi-organellar protein located in the mitochondria and the nucleus, is implicated in cell respiration, survival, and response to tissue hypoxia. Recently, the reduction of the cellular CHCHD2/MNRR1 protein, as part of mitochondrial dysfunction, has been shown to play a role in the amplification of inflammatory cytokines in a murine model of lipopolysaccharide-induced systemic inflammation. The aim of this study was to determine whether the plasma concentration of CHCHD2/MNRR1 changed during human normal pregnancy, spontaneous labor at term, and clinical chorioamnionitis at term. METHODS: We conducted a cross-sectional study that included the following groups: 1) non-pregnant women (n = 17); 2) normal pregnant women at various gestational ages from the first trimester until term (n = 110); 3) women at term with spontaneous labor (n = 50); and 4) women with clinical chorioamnionitis at term in labor (n = 25). Plasma concentrations of CHCHD2/MNRR1 were assessed by an enzyme-linked immunosorbent assay. RESULTS: 1) Pregnant women at term in labor with clinical chorioamnionitis had a significantly higher plasma CHCHD2/MNRR1 concentration than those in labor without chorioamnionitis (p = .003); 2) CHCHD2/MNRR1 is present in the plasma of healthy non-pregnant and normal pregnant women without significant differences in its plasma concentrations between the two groups; 3) there was no correlation between maternal plasma CHCHD2/MNRR1 concentration and gestational age at venipuncture; and 4) plasma CHCHD2/MNRR1 concentration was not significantly different in women at term in spontaneous labor compared to those not in labor. CONCLUSIONS: CHCHD2/MNRR1 is physiologically present in the plasma of healthy non-pregnant and normal pregnant women, and its concentration does not change with gestational age and parturition at term. However, plasma CHCHD2/MNRR1 is elevated in women at term with clinical chorioamnionitis. CHCHD2/MNRR1, a novel bi-organellar protein located in the mitochondria and the nucleus, is released into maternal plasma during systemic inflammation.