Optimization of Ag-TiO<inf>2</inf> nanocomposite at a low toxicity dose as a self-virucidal disinfectant against COVID-19
Issued Date
2023-01-01
Resource Type
ISSN
25225731
eISSN
2522574X
Scopus ID
2-s2.0-85163138153
Journal Title
Emergent Materials
Rights Holder(s)
SCOPUS
Bibliographic Citation
Emergent Materials (2023)
Suggested Citation
Jariyaboon M., Masrinoul P., Komaikul J., Muenkaew K., Juntarapornchai S., Ketsuwan K., Rodpai E., Ruangdachsuwan S., Palabodeewat S., Chitichotpanya C. Optimization of Ag-TiO<inf>2</inf> nanocomposite at a low toxicity dose as a self-virucidal disinfectant against COVID-19. Emergent Materials (2023). doi:10.1007/s42247-023-00520-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87817
Title
Optimization of Ag-TiO<inf>2</inf> nanocomposite at a low toxicity dose as a self-virucidal disinfectant against COVID-19
Author's Affiliation
Other Contributor(s)
Abstract
Self-virucidal Ag-TiO2 nanocomposites at low toxicity dose could be a viable solution to reduce the risks posed by SARS-CoV-2 infection and excessive usage of disinfectants. We synthesized an Ag-TiO2 nanocomposite suspension in a simple, low energy consumption, eco-friendly, one-pot process. PVP and SDS were used in a 3:1 ratio as co-stabilizers, resulting in a uniform size with high stability. The nanocomposite characterization used UV–Vis spectroscopy, high-resolution transmission-electron-microscopy equipped with an energy dispersive X-ray spectroscope (HR-TEM, EDX), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). We determined the virucidal efficacy against SARS-CoV-2 by following ASTM E1052-20. The cytotoxicity test followed ISO 10993–5:2009. At high doses (50 ppm), the Ag-TiO2 nanocomposite suspension showed ≥ 99.96% virucidal efficacy within 1 min, damaging the viral genome. At a low dosage (0.8 ppm), the viral infectivity was reduced by 99.86% within 24 h and minimized cytotoxicity. The viral protein had denatured, while the viral genome remained intact. The results suggest that the Ag-TiO2 nanocomposite can be used in a more eco-friendly and safer manner as a potent broad spectrum virucidal disinfectant, offering broad action against unspecified targets (all virus proteins, not just the spike proteins), which could be helpful in all SARS-CoV-2 variants of concern.