Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep
Issued Date
2023-10-01
Resource Type
ISSN
22135979
Scopus ID
2-s2.0-85168802317
Journal Title
Photoacoustics
Volume
33
Rights Holder(s)
SCOPUS
Bibliographic Citation
Photoacoustics Vol.33 (2023)
Suggested Citation
Benavides-Lara J., Manwar R., McGuire L.S., Islam M.T., Shoo A., Charbel F.T., Menchaca M.G., Siegel A.P., Pillers D.A.M., Gelovani J.G., Avanaki K. Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep. Photoacoustics Vol.33 (2023). doi:10.1016/j.pacs.2023.100549 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/89286
Title
Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep
Other Contributor(s)
Abstract
Intraventricular (IVH) and periventricular (PVH) hemorrhages in preterm neonates are common because the periventricular blood vessels are still developing up to 36 weeks and are fragile. Currently, transfontanelle ultrasound (US) imaging is utilized for screening for IVH and PVH, largely through the anterior fontanelle. However for mild hemorrhages, inconclusive diagnoses are common, leading to failure to detect IVH/PVH or, when other clinical symptoms are present, use of second stage neuroimaging modalities requiring transport of vulnerable patients. Yet even mild IVH/PVH increases the risk of moderate-severe neurodevelopmental impairment. Here, we demonstrate the capability of transfontanelle photoacoustic imaging (TFPAI) to detect IVH and PVH in-vivo in a large animal model. TFPAI was able to detect IVH/PVH as small as 0.3 mL in volume in the brain (p < 0.05). By contrast, US was able to detect hemorrhages as small as 0.5 mL. These preliminary results suggest TFPAI could be translated into a portable bedside imaging probe for improved diagnosis of clinically relevant brain hemorrhages in neonates.