Publication: Hepatic metabolism in severe falciparum malaria: Caffeine clearance study
Issued Date
1994-01-01
Resource Type
ISSN
00034983
Other identifier(s)
2-s2.0-0028204048
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Annals of Tropical Medicine and Parasitology. Vol.88, No.1 (1994), 13-19
Suggested Citation
P. Wilairatana, S. Looareesuwan, S. Vanijanonta, P. Charoenlarp, S. Wittayalertpanya Hepatic metabolism in severe falciparum malaria: Caffeine clearance study. Annals of Tropical Medicine and Parasitology. Vol.88, No.1 (1994), 13-19. doi:10.1080/00034983.1994.11812829 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9593
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Hepatic metabolism in severe falciparum malaria: Caffeine clearance study
Other Contributor(s)
Abstract
Falciparum malaria is known to cause abnormalities in the liver. Hepatic metabolism in patients with falciparum was studied by caffeine clearance and the results were related to the severity of the disease. Caffeine (3.5 mg/kg) was administered orally to patients with severe (N= 10) or uncomplicated (N=9) falciparum malaria. The plasma clearances during illness averaged 0.67 ± 0.27 ml/min kg for the severe cases and 0.98 ± 0.36 ml/min kg for the uncomplicated cases (P < 0.05). In the severe patients, clearances during illness (0.67 ± 0.27 ml/min kg) were less than those in convalescence (2.15 ± 0.91 ml/min kg) (P < 0.0001). However, in the uncomplicated cases, the clearances during illness and in convalescence were similar (P > 0.05) and clearance rates in convalescence were similar for the severe and uncomplicated cases (p > 0.05) Hepatic microsomal metabolism is apparently slow in severe falciparum malaria but reverts to normal in convalescence. Liver metabolic function does not appear to be significantly affected in uncomplicated malaria.