CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area
Issued Date
2024-01-01
Resource Type
ISSN
20499434
eISSN
20499442
Scopus ID
2-s2.0-85184218365
Journal Title
Biomedical Reports
Volume
20
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomedical Reports Vol.20 No.1 (2024)
Suggested Citation
Jiraboonsri S., Hemvipat P., Kamolratanakul S., Bhummaphan N., Siritientong T., Kitkumthorn N., Mutirangura A., Meevassana J. CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area. Biomedical Reports Vol.20 No.1 (2024). doi:10.3892/BR.2023.1693 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97175
Title
CpG methylation changes in Alu repetitive sequences in normal aging due to diastolic hypertension in human dermal fibroblasts from the facial area
Corresponding Author(s)
Other Contributor(s)
Abstract
Aging fibroblasts, an important factor contrib-uting to skin aging, are affected by numerous mechanisms, including alterations in DNA methylation and age-related diseases. The current study aimed to investigate the role of Alu methylation in aging fibroblasts and hypertension. The Alu methylation levels in dermal fibroblasts obtained from patients of different ages and blood pressure status were analyzed using the combined bisulfite restriction analysis technique. An inverse correlation was observed between Alu methylation in dermal fibroblasts and patient age. Dermal fibroblasts from the high-normal diastolic blood pressure group had higher Alu methylation levels compared with those from the normal group. The findings of the present study suggest that Alu methylation alterations can be observed with chronological aging and hypertension, and are a potential aging marker or therapeutic target.