Lower Plasma Selenium Level in Primary Malignant Bone Tumors: A Survey Research
Issued Date
2024-01-01
Resource Type
eISSN
22288082
Scopus ID
2-s2.0-85195686232
Journal Title
Siriraj Medical Journal
Volume
76
Issue
6
Start Page
333
End Page
338
Rights Holder(s)
SCOPUS
Bibliographic Citation
Siriraj Medical Journal Vol.76 No.6 (2024) , 333-338
Suggested Citation
Sutthipongkiat C., Attatippaholkun W., Srisamutnak S., Waikakul S., Chotiyarnwong P. Lower Plasma Selenium Level in Primary Malignant Bone Tumors: A Survey Research. Siriraj Medical Journal Vol.76 No.6 (2024) , 333-338. 338. doi:10.33192/smj.v76i6.266822 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98821
Title
Lower Plasma Selenium Level in Primary Malignant Bone Tumors: A Survey Research
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Abstract
Objective: To compare plasma selenium levels in primary bone tumor patients with clinically healthy Thai subjects. Materials and Methods: A cross-sectional study on plasma selenium of primary bone tumor patients aged above 12 years old was obtained at Siriraj Hospital. The plasma samples were used for selenium assay by Electrothermal Atomic Absorption spectrometry method. The plasma selenium levels were compared with the clinically healthy Thai subjects or within primary bone tumor groups (age: below or above 30 years, gender: male or female, benign or malignant tumor, metastasis or non-metastasis). Results: One hundred and nine primary bone tumor patients were included in this study. Plasma selenium level in clinically healthy Thai subjects aged more than 30 years old was significantly higher than a primary bone tumor group (121.71 ± 19.96 μg/L vs 111.88 ± 23.62 μg/L, mean difference -9.83, p-value = 0.017). The plasma selenium levels within the primary bone tumor patients did not exhibit significant differences when compared across genders, age groups below and above 30 years old, benign and malignant tumors, or between metastatic and non-metastatic tumor cases. Conclusion: A patient with a history of malignant bone tumors tends to have a lower level of plasma selenium than normal people. However, the study of selenium supplementation for those who have a higher risk of developing malignant bone tumors is needed in the future.