Potential Cutaneous Applications of Boesenbergia rotunda Extract Based on Its In Vitro Anti-Melanogenic and Anti-Fibroproliferative Properties
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Issued Date
2025-05-01
Resource Type
ISSN
16616596
eISSN
14220067
Scopus ID
2-s2.0-105004930744
Journal Title
International Journal of Molecular Sciences
Volume
26
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences Vol.26 No.9 (2025)
Suggested Citation
Salakshna N., Thanasarnaksorn W., Kanjanasirirat P., Jearawuttanakul K., Chabang N., Rangkansenee N., Panich U., Thanachaiphiwat S., Borwornpinyo S., Hongeng S. Potential Cutaneous Applications of Boesenbergia rotunda Extract Based on Its In Vitro Anti-Melanogenic and Anti-Fibroproliferative Properties. International Journal of Molecular Sciences Vol.26 No.9 (2025). doi:10.3390/ijms26094319 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110244
Title
Potential Cutaneous Applications of Boesenbergia rotunda Extract Based on Its In Vitro Anti-Melanogenic and Anti-Fibroproliferative Properties
Corresponding Author(s)
Other Contributor(s)
Abstract
The rhizomes of Boesenbergia rotunda (fingerroot) and its bioactive compound, panduratin A, exhibit potent anti-inflammatory, antioxidant, and anti-proliferative properties. The aim of this study was to investigate the anti-melanogenic (including anti-tyrosinase) effects of B. rotunda extract and panduratin A in B16F10 melanoma cells induced by UVA radiation. The effects of the compounds on fibroblast proliferation and migration were also assessed by scratch wound healing assays in human primary fibroblasts. The results showed that B. rotunda extract and panduratin A significantly reduced tyrosinase activity and cellular melanogenesis induced by UVA radiation in a dose-dependent manner. The compounds also demonstrated inhibitory effects on fibroblast cell migration and proliferation. These findings suggest that B. rotunda extract may have potential therapeutic effects on skin hyperpigmentation and fibroproliferative skin disorders.