Potential Cutaneous Applications of Boesenbergia rotunda Extract Based on Its In Vitro Anti-Melanogenic and Anti-Fibroproliferative Properties

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dc.contributor.authorSalakshna N.
dc.contributor.authorThanasarnaksorn W.
dc.contributor.authorKanjanasirirat P.
dc.contributor.authorJearawuttanakul K.
dc.contributor.authorChabang N.
dc.contributor.authorRangkansenee N.
dc.contributor.authorPanich U.
dc.contributor.authorThanachaiphiwat S.
dc.contributor.authorBorwornpinyo S.
dc.contributor.authorHongeng S.
dc.contributor.correspondenceSalakshna N.
dc.contributor.otherMahidol University
dc.date.accessioned2025-05-20T18:13:26Z
dc.date.available2025-05-20T18:13:26Z
dc.date.issued2025-05-01
dc.description.abstractThe rhizomes of Boesenbergia rotunda (fingerroot) and its bioactive compound, panduratin A, exhibit potent anti-inflammatory, antioxidant, and anti-proliferative properties. The aim of this study was to investigate the anti-melanogenic (including anti-tyrosinase) effects of B. rotunda extract and panduratin A in B16F10 melanoma cells induced by UVA radiation. The effects of the compounds on fibroblast proliferation and migration were also assessed by scratch wound healing assays in human primary fibroblasts. The results showed that B. rotunda extract and panduratin A significantly reduced tyrosinase activity and cellular melanogenesis induced by UVA radiation in a dose-dependent manner. The compounds also demonstrated inhibitory effects on fibroblast cell migration and proliferation. These findings suggest that B. rotunda extract may have potential therapeutic effects on skin hyperpigmentation and fibroproliferative skin disorders.
dc.identifier.citationInternational Journal of Molecular Sciences Vol.26 No.9 (2025)
dc.identifier.doi10.3390/ijms26094319
dc.identifier.eissn14220067
dc.identifier.issn16616596
dc.identifier.scopus2-s2.0-105004930744
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/123456789/110244
dc.rights.holderSCOPUS
dc.subjectChemical Engineering
dc.subjectChemistry
dc.subjectBiochemistry, Genetics and Molecular Biology
dc.subjectComputer Science
dc.titlePotential Cutaneous Applications of Boesenbergia rotunda Extract Based on Its In Vitro Anti-Melanogenic and Anti-Fibroproliferative Properties
dc.typeArticle
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105004930744&origin=inward
oaire.citation.issue9
oaire.citation.titleInternational Journal of Molecular Sciences
oaire.citation.volume26
oairecerif.author.affiliationFaculty of Science, Mahidol University
oairecerif.author.affiliationRamathibodi Hospital
oairecerif.author.affiliationSiriraj Hospital
oairecerif.author.affiliationSamitivej Hospital (Sukhumvit)
oairecerif.author.affiliationMahidol University
oairecerif.author.affiliationThammasat University
oairecerif.author.affiliationInstitute of Molecular Biosciences, Mahidol University

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