ent-Clavilactone J and Its Quinone Derivative, Meroterpenoids from the Fungus Resupinatus sp.
Issued Date
2023-01-01
Resource Type
ISSN
01633864
eISSN
15206025
Scopus ID
2-s2.0-85178247603
Pubmed ID
37931226
Journal Title
Journal of Natural Products
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Natural Products (2023)
Suggested Citation
Harms K., Paomephan P., Boonpratuang T., Choeyklin R., Boonchird C., Surup F. ent-Clavilactone J and Its Quinone Derivative, Meroterpenoids from the Fungus Resupinatus sp.. Journal of Natural Products (2023). doi:10.1021/acs.jnatprod.3c00174 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91395
Title
ent-Clavilactone J and Its Quinone Derivative, Meroterpenoids from the Fungus Resupinatus sp.
Other Contributor(s)
Abstract
Metabolites 1 and 2, isolated from cultures of the basidiomycete Resupinatus sp. BCC84615, collected in a tropical forest in northeastern Thailand, showed weak antibiotic activity against Bacillus subtilis and Staphylococcus aureus and cytotoxicity against cancer cell lines. Their planar structures were elucidated by high-resolution electrospray ionization mass spectrometry and NMR spectroscopy as clavilactone J, known from the basidiomycete Ampulloclitocybe clavipes, and its new 1,4-benzoquinone derivative. A detailed analysis of the ROESY correlations in 1 confirmed the recent revision of the relative configuration of clavilactone J. However, specific rotation and Cotton effects observed by electronic circular dichroism were contrary to those of the clavilactones; thus, we assigned a rare antipodal absolute configuration.